Ligases

A class of enzymes that catalyze the formation of a bond between two substrate molecules, coupled with the hydrolysis of a pyrophosphate bond in ATP or a similar energy donor. (Dorland, 28th ed) EC 6.

Also Known As:

Networked: 2113 relevant articles (46 outcomes, 157 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Xu, Guang-Yin: 11 articles (07/2015 - 01/2009)
2.	Glass, David J: 11 articles (05/2014 - 02/2003)
3.	Sun, Yi: 10 articles (06/2014 - 11/2003)
4.	Silverman, Robert H: 8 articles (06/2014 - 01/2003)
5.	van der Donk, Wilfred A: 8 articles (02/2011 - 02/2006)
6.	Jiang, Xinghong: 7 articles (01/2015 - 01/2012)
7.	Willis, Monte S: 7 articles (01/2015 - 12/2009)
8.	Hasselgren, Per-Olof: 7 articles (10/2013 - 05/2003)
9.	Häberle, Johannes: 6 articles (11/2015 - 05/2004)
10.	Benveniste, Olivier: 6 articles (07/2015 - 06/2011)

Related Diseases

1.	Neoplasms (Cancer) 04/01/1986 - "It is postulated that PG synthetase inhibitor may prove to be a good therapeutic tool effective against human cancer when used in combination with chemotherapeutic and other immunotherapeutic drugs as well as with low-dose radiation therapy." 01/01/2015 - "Ubiquitination by E3 ligases may induce cellular relocation of p53 and determine the outcome of p53-mediated stress response, including cell proliferation, apoptosis and efficacy of cancer therapy. " 04/01/2013 - "RING E3 ligases have the subject of intense studies for their roles in many diseases including cancer and as potential therapeutic targets. " 08/01/2005 - "Studies on the tumor suppressor p53 have indeed demonstrated that poly-ubiquitination of p53 by different E3 ubiquin ligases targets p53 for degradation by the 26S proteasomes. " 09/01/1992 - "Progestin-induced fatty acid synthetase in human mammary tumors: from molecular to clinical studies."
2.	Infection 01/01/2015 - "The tomato SlHUB1 and SlHUB2 had H2B monoubiquitination E3 ligases activity in vitro and expression of SlHUB1 and SlHUB2 was induced by infection of B. " 12/01/2014 - "After IAV infection, viral levels were increased 2-fold in hBECs from asthmatic subjects compared with nonasthmatic control subjects (P < .05) and this increase occurred in concert with increased IFN-λ1 levels and no significant difference in IFNB1, 2'-5'-oligoadenylate synthetase 1, or myxovirus (influenza virus) resistance 1mRNA levels. " 09/01/2014 - "Association of dengue virus infection susceptibility with polymorphisms of 2'-5'-oligoadenylate synthetase genes: a case-control study." 04/01/2014 - "These data suggest that there are infection-phase-specific and anatomically compartmentalized differences in TRIM5α and TRIM22 regulation involving primarily IFN-I and specific cell types and indicate subtle differences in the antiviral roles and transcriptional regulation of TRIM E3 ligases in vivo. " 11/01/2013 - "The sidE gene encodes a bimodular peptide synthetase and was shown previously to be strongly upregulated during initiation of murine lung infection. "
3.	Myositis (Idiopathic Inflammatory Myopathies) 09/01/2015 - "Combining these facets of Jo-1-mediated immunity now supports a more integrated model of disease pathogenesis that should lead to improved therapeutic targeting in the anti-synthetase syndrome and related subsets of idiopathic inflammatory myopathy." 12/01/2006 - "They have improved the diagnosis of myositis by leading to the identification of characteristic clinical patterns, such as anti-synthetase syndrome. " 12/01/2015 - "We used four different immunodot kits (D-Tek, Mons, Belgium): ANA25 Quantrix, Synthetase 10 Diver, Myositis 7 Diver and Liver 10 profile Diver, all automatized on the BlueDiver Instrument (D-Tek). " 11/21/2015 - "A case of anti-PL7 antibody positive myositis and a clinical and pathological review of the anti-synthetase syndrome." 04/01/2014 - "Idiopathic inflammatory myopathies and the anti-synthetase syndrome: a comprehensive review."
4.	Reperfusion Injury 08/01/2004 - "Poly(adenosine 5'-diphosphate-ribose) synthetase (PARS) inhibitor has been suggested to attenuate the ischemia-reperfusion injury in myocardial infarction by preventing energy depletion associated with oxidative stress. " 06/01/2004 - "Intratracheal poly (ADP) ribose synthetase inhibition ameliorates lung ischemia reperfusion injury." 01/01/1984 - "These data suggest an efficacy of PGI2 administration but not of TX synthetase inhibition in preserving the myocardium from reperfusion injury. " 02/01/2001 - "The present study was undertaken to determine the possible deleterious role played by poly(adenosine diphosphate-ribose) synthetase (PARS) in cochlear ischemia-reperfusion injury. " 02/15/2014 - "Inhibition of long chain fatty acyl-CoA synthetase (ACSL) and ischemia reperfusion injury."
5.	Muscular Atrophy (Muscle Atrophy) 01/01/2008 - "Here, we show that intraperitoneal injection of endotoxin (lipopolysaccharide, LPS) in mice resulted in higher level of ROS and greater expression of muscle-specific E3 ubiqitin ligases, muscle atrophy F-box (MAFbx)/atrogin-1 and muscle RING finger-1 (MuRF1), in glycolytic white vastus lateralis muscle than in oxidative soleus muscle. " 11/04/2011 - "Blocking the expression of these two ubiquitin ligases provides protection against muscle atrophy. " 01/01/2007 - "The present study determined whether thermal injury increases the expression of the ubiquitin (Ub) E3 ligases referred to as muscle ring finger (MuRF)-1 and muscle atrophy F-box (MAFbx; aka atrogin-1), which are muscle specific and responsible for the increased protein breakdown observed in other catabolic conditions. " 05/01/2015 - "Muscle atrophy F-Box (MAFbx)/atrogin-1 and muscle ring-finger-1 (MuRF-1) have been identified as two muscle-specific E3 ubiquitin ligases that are highly expressed in skeletal muscle during muscle atrophy. " 01/01/2015 - "Finally, we identify FoxO-dependent ubiquitin ligases including MUSA1 and a previously uncharacterised ligase termed SMART (Specific of Muscle Atrophy and Regulated by Transcription). "

Related Drugs and Biologics

1.	Ubiquitin
2.	Poly Adenosine Diphosphate Ribose
3.	gamma-glutamylcysteine
4.	Acyl Coenzyme A (Acyl CoA)
5.	Nitric Oxide (Nitrogen Monoxide)
6.	Carbamyl Phosphate (Carbamoyl Phosphate)
7.	Glutathione (Reduced Glutathione)
8.	ozagrel
9.	Epoprostenol (Prostacyclin)
10.	DNA (Deoxyribonucleic Acid)

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)
3.	Aftercare (After-Treatment)
4.	Denervation
5.	Transplantation (Transplant Recipients)