There was significant difference (F=78.96, P<0.01) in
NF-kappaB activity among normal lung tissue group (24,826+/-3724),
squamous-cell carcinoma tissue group (28,028+/-4204), and
adenocarcinoma tissue group (35,425+/-5317). The
NF-kappaB activity in the
squamous-cell carcinoma group and the adenocarcinom tissue group was higher than that in the normal lung tissue group (all P<0.01); and the
NF-kappaB activity is in the
adenocarcinoma tissue group was higher compared with that in the
squamous-cell carcinoma group (P<0.05). There was significant difference (F=62.43, P<0.01) in the cyclinD1
mRNA level among normal lung tissue group (2.04+/-0.24), the
squamous-cell carcinoma group (2.91+/-0.37), and the
adenocarcinoma group (4.13+/-0.36). There was significant difference (F=89.24, P<0.01) in cyclinD1
protein level among normal lung tissue group (0.31+/-0.06), the
squamous-cell carcinoma group (0.43+/-0.07), and the
adenocarcinoma group (0.58+/-0.08). There was significant difference (F=45.61, P<0.01) in
PCNA protein level among the normal lung tissue group (0.32+/-0.09), the
squamous-cell carcinoma group (0.42+/-0.10), and the adenocarcinima group (0.54+/-0.16). There was no significant difference (F=1.86, P>0.05) in apoptosis index among the normal lung tissue group (2.58%+/-0.39%), the
squamous-cell carcinoma group (2.27%+/-0.34%), and the
adenocarcinoma group (2.92%+/-0.59%). The
NF-kappaB activity was positively correlated with
cyclin D1 mRNA level,
cyclin D1 protein level, and
PCNA protein level in the
squamous-cell carcinoma group (r=0.51, P<0.05, r=0.54, P<0.05, r=0.60, P<0.05), respectively; the
NF-kappaB activity was also positively correlated with cyclinD1mRNA, cyclinD1protein level, and
PCNA protein level in the
adenocarcinoma group (r=0.60, P<0.05; r=0.64, P<0.05; r=0.68, P<0.05), respectively. The
NF-kappaB activity in the squamous-cell group and the
adenocarcinoma group was not related to cell apoptosis index.
CONCLUSION: