Melatonin receptors mediate improvements of liver function but not of hepatic perfusion and integrity after hemorrhagic shock in rats.
Abstract | OBJECTIVE: DESIGN: Prospective, randomized, controlled study. SETTING: University research laboratory. SUBJECTS: Male Sprague-Dawley rats, 200-300 g (n = 10 per group). INTERVENTIONS: MEASUREMENTS AND MAIN RESULTS: After 2 hrs of reperfusion, either liver function was assessed by plasma disappearance rate of indocyanine green or intravital microscopy of the liver was performed for evaluation of hepatic perfusion, hepatocellular redox state, and hepatic integrity. Compared with vehicle controls, melatonin therapy after hemorrhagic shock significantly improved plasma disappearance rate of indocyanine green, hepatic redox state, hepatocellular injury, and hepatic perfusion index. Coadministration of luzindole completely abolished the protective effect with respect to liver function only, and improvements regarding hepatic redox state, perfusion, and integrity were comparable with melatonin treatment alone. CONCLUSIONS:
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Authors | Alexander M Mathes, Darius Kubulus, Julia Weiler, Alexander Bentley, Lina Waibel, Beate Wolf, Inge Bauer, Hauke Rensing |
Journal | Critical care medicine
(Crit Care Med)
Vol. 36
Issue 1
Pg. 24-9
(Jan 2008)
ISSN: 1530-0293 [Electronic] United States |
PMID | 18090374
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antioxidants
- Coloring Agents
- Receptors, Melatonin
- NADP
- Indocyanine Green
- Melatonin
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Topics |
- Animals
- Antioxidants
(therapeutic use)
- Coloring Agents
(metabolism)
- Disease Models, Animal
- Indocyanine Green
(metabolism)
- Liver
(blood supply, drug effects, metabolism, physiopathology)
- Liver Function Tests
- Male
- Melatonin
(therapeutic use)
- Microcirculation
(drug effects, physiopathology)
- NADP
(metabolism)
- Prospective Studies
- Random Allocation
- Rats
- Rats, Sprague-Dawley
- Receptors, Melatonin
(drug effects, metabolism)
- Reference Values
- Shock, Hemorrhagic
(drug therapy, metabolism, physiopathology)
- Treatment Outcome
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