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Indocyanine Green (Cardio-Green)

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A tricarbocyanine dye that is used diagnostically in liver function tests and to determine blood volume and cardiac output.

Also Known As:

Cardio-Green; Cardiogreen; Ujoveridin; Vofaverdin; Vophaverdin; Wofaverdin; Cardio Green; Green, Indocyanine; 1H-Benz(e)indolium, 2-(7-(1,3-dihydro-1,1-dimethyl-3-(4-sulfobutyl)-2H-benz(e)indol-2-ylidene)-1,3,5-heptatrienyl)-1,1-dimethyl-3-(4-sulfobutyl)-, inner salt, sodium salt

Networked: 2163 relevant articles (128 outcomes, 193 trials/studies)

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Drug Context: Research Results

Heterocyclic Compounds: 60
- 2-Ring Heterocyclic Compounds
  - Indoles: 95
    - Indocyanine Green: 2163

Experts

1.	Herbort, Carl P: 17 articles (04/2015 - 04/2002)
2.	Koshima, Isao: 16 articles (12/2014 - 08/2007)
3.	Yamamoto, Takumi: 15 articles (11/2015 - 05/2011)
4.	Mihara, Makoto: 15 articles (08/2015 - 08/2007)
5.	Narushima, Mitsunaga: 15 articles (12/2014 - 08/2007)
6.	Kokudo, Norihiro: 14 articles (05/2015 - 02/2009)
7.	Iida, Takuya: 13 articles (09/2015 - 10/2011)
8.	Frangioni, John V: 12 articles (02/2015 - 11/2010)
9.	Kampik, Anselm: 12 articles (10/2009 - 04/2002)
10.	Iida, Tomohiro: 11 articles (09/2015 - 01/2002)

Related Diseases

1.	Neoplasms (Cancer) 04/01/2012 - "Multivariate analysis revealed that: 1) indocyanine green retention rate at 15 minutes; 2) disease-free interval; 3) tumor size; 4) portal vein invasion at primary Hx; 5) gender; and 6) estimated blood loss to be an independent and significant poor prognostic factors. " 04/01/2012 - "Indocyanine green videography and real-time evaluation by FLOW 800 were objective and effective for the excision of a tumor retaining the arteriovenous shunt. " 07/01/2011 - "Intraoperative imaging of indocyanine green with near infrared fluorescence is a safe and effective method to accurately identify the renal vasculature and to differentiate renal tumors from surrounding normal parenchyma. " 08/01/2010 - "Value of indocyanine green clearance of the future liver remnant in predicting outcome after resection for biliary cancer." 08/01/2009 - "Application of a biodegradable macromolecular contrast agent in dynamic contrast-enhanced MRI for assessing the efficacy of indocyanine green-enhanced photothermal cancer therapy."
2.	Choroidal Neovascularization 12/01/2014 - "To evaluate the efficacy of spectral-domain optical coherence tomography (SD OCT) compared to indocyanine green angiography (ICGA) in detecting idiopathic polypoidal choroidal vasculopathy (PCV) and in differentiating between PCV and occult choroidal neovascularization (CNV). " 03/01/2000 - "This study aimed to determine whether indocyanine green (ICG) angiography is useful to identify the ingrowth site of idiopathic choroidal neovascularization (CNV), which can predict visual outcomes after surgical removal of idiopathic CNV. " 09/01/1998 - "Recent studies have shown that indocyanine-green videoangiography (ICG-V) is useful to image occult choroidal neovascularization. " 04/01/1998 - "This study aimed to use a new technique for ocular imaging, digital subtraction indocyanine green angiography (DS-ICGA), to evaluate patients with occult choroidal neovascularization (CNV). " 03/01/1995 - "Several studies have shown that indocyanine green (ICG) angiography improves the detection of occult choroidal neovascularization (CNV). "
3.	Macular Degeneration (Age-Related Maculopathy) 08/01/2000 - "Indocyanine green angiography has been reported to improve detection and delineation of occult choroidal neovascularisation in serous pigment epithelium detachment in age-related macular degeneration. " 09/01/1997 - "Indocyanine green angiography may help to distinguish the different types of drusen and may thus be of use in evaluating the risk of progressive age-related macular degeneration in patients with drusen." 07/01/2015 - "This study aimed to evaluate the utility of indocyanine green (ICG) angiography in predicting recalcitrance in neovascular age-related macular degeneration (nAMD). " 10/01/2007 - "Among the participants in the Japanese Age-Related Macular Degeneration Trial (JAT) at our hospital, a PCV was seen in three eyes at baseline on retrospective analysis of indocyanine green angiography (ICGA) using fundus camera. " 08/01/2004 - "To study the effectiveness of indocyanine green mediated photothrombosis in the management of predominantly classic subfoveal choroidal neovascularisation associated with age related macular degeneration. "
4.	Liver Diseases (Liver Disease) 12/01/1987 - "A non-invasive method of estimating liver blood flow by a two-compartment pharmacokinetic model of the plasma clearance of indocyanine green has been previously described in normal animals and patients without liver disease. " 04/01/1982 - "Half-life time or clearance of indocyanine green in patients with liver disease." 05/01/1975 - "[Plasma clearance of indocyanine green (Ujoviridin) in liver diseases (author's transl)]." 08/01/1999 - "Experimental study of liver dysfunction evaluated by direct indocyanine green clearance using near infrared spectroscopy." 12/01/1972 - "[Clinical studies on hepatic excretion mechanism of indocyanine green in liver diseases]."
5.	Central Serous Chorioretinopathy 05/01/1996 - "Advanced methods for indocyanine green (ICG) video-fluorescence angiography provide improved evaluation of choroidal blood flow disturbances in patients with central serous chorioretinopathy (CSC). " 05/01/2010 - "The purpose of this study was to examine indocyanine green angiography of eyes with central serous chorioretinopathy (CSC). " 01/01/1995 - "The purpose of this study is to better characterise, on the basis of a large number of cases and follow-up evaluations, choroidal abnormalities recently observed with indocyanine green (ICG) angiography in central serous chorioretinopathy (CSC). " 08/01/2014 - "To describe the spectrum of ultra-widefield autofluorescence (AF) and indocyanine green (ICG) angiographic findings in central serous chorioretinopathy (CSC). " 08/01/2014 - "Ultra-widefield imaging with autofluorescence and indocyanine green angiography in central serous chorioretinopathy."

Related Drugs and Biologics

1.	1-phenyl-3,3-dimethyltriazene (PDT)
2.	Fluorescein (Funduscein)
3.	Retinaldehyde (Retinal)
4.	Antipyrine (Phenazone)
5.	Galactose (Galactopyranose)
6.	Trypan Blue
7.	Verapamil (Calan)
8.	verteporfin (Visudyne)
9.	Ammonia
10.	Indocyanine Green (Cardio-Green)

Related Therapies and Procedures

1.	Lasers (Laser)
2.	Photochemotherapy (Photodynamic Therapy)
3.	Light Coagulation
4.	Semiconductor Lasers
5.	Hepatectomy