Genotyping and genomic sequencing in clinical practice.

Abstract	The global prevalence of chronic hepatitis B and its associated serious sequelae demand technologically advanced techniques of management. Nucleic acid testing (NAT) plays a key role in the diagnosis, surveillance, and treatment of chronic hepatitis B. NAT includes quantitative PCR-based HBV DNA assays, HBV genotyping, tests for mutations associated with resistance to antiviral medications, and assays to detect precore and core promoter mutations. This article reviews the uses of NAT in the diagnosis and management of chronic hepatitis B.
Authors	Robert G Gish, Stephen Locarnini
Journal	Clinics in liver disease (Clin Liver Dis) Vol. 11 Issue 4 Pg. 761-95, viii (Nov 2007) ISSN: 1089-3261 [Print] United States
PMID	17981228 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
Chemical References	Antiviral Agents DNA, Viral
Topics	Antiviral Agents (therapeutic use) DNA, Viral (blood) Genotype Hepatitis B virus (genetics) Hepatitis B, Chronic (blood, drug therapy, virology) Humans Sequence Analysis, DNA

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