Abstract | OBJECTIVE: In pregestational diabetes, the placenta at term of gestation is characterized by various structural and functional changes. Whether similar alterations occur in the first trimester has remained elusive. Placental development requires proper trophoblast invasion and tissue remodeling, processes involving matrix metalloproteinases ( MMPs) of which the membrane-anchored members (MT- MMPs) such as MT1-MMPs are key players. Here, we hypothesize a dysregulation of placental MT1-MMP in the first trimester of type 1 diabetic pregnancies induced by the diabetic environment. RESEARCH DESIGN AND METHODS: RESULTS: CONCLUSIONS: This is the first study reporting alterations in the first-trimester placenta in type 1 diabetes. The upregulated MT1-MMP expression in type 1 diabetes may be the result of higher maternal insulin and TNF-alpha levels. We speculate that the elevated MT1-MMP will affect placental development and may thus contribute to long-term structural alterations in the placenta in pregestational diabetes.
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Authors | Ursula Hiden, Elisabeth Glitzner, Marina Ivanisevic, Josip Djelmis, Christian Wadsack, Uwe Lang, Gernot Desoye |
Journal | Diabetes
(Diabetes)
Vol. 57
Issue 1
Pg. 150-7
(Jan 2008)
ISSN: 1939-327X [Electronic] United States |
PMID | 17928399
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Insulin
- Tumor Necrosis Factor-alpha
- MMP14 protein, human
- Matrix Metalloproteinase 14
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Topics |
- Abortion, Spontaneous
(enzymology, genetics)
- Cell Culture Techniques
- Diabetes Mellitus, Type 1
(complications, enzymology, genetics)
- Female
- Gene Expression Regulation, Enzymologic
- Humans
- Insulin
(blood)
- Matrix Metalloproteinase 14
(genetics)
- Placenta
(enzymology)
- Pregnancy
- Pregnancy Complications
(enzymology, genetics)
- Pregnancy Trimester, First
- Reference Values
- Trophoblasts
(cytology, enzymology)
- Tumor Necrosis Factor-alpha
(blood)
- Up-Regulation
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