Abstract | BACKGROUND: METHODS: RESULTS: During the follow-up period, 89 deaths (53 from cardiovascular causes) were observed. After adjustment for age, gender, dialysis vintage, smoking, diabetes mellitus and hypertension, the highest tertile of CRP and lowest tertile of transthyretin and CI were significantly associated with all-cause mortality (relative risk (RR)=1.98 [1.12-3.47], 2.58 [1.48-4.50], 2.71 [1.42-5.19], respectively). In addition, low CI had an additive value to low levels of transthyretin. In contrast, high cholesterol (RR=0.47 [0.27-0.83], P=0.0091) and vitamin E concentrations (RR=0.46 [0.26-0.80], P= 0.006) showed a protective trend for all-cause mortality. In the multivariate analysis, transthyretin appeared as the most predictive biological marker of non-CV mortality (RR=3.78 [1.30-10.96], P=0.014), and CI of CV mortality (RR=2.61 [1.06-6.46], P=0.038), respectively. Discussion. These results confirm that uraemic malnutrition constitutes an important risk factor for mortality in HD. Beyond transthyretin, CI seems to be an additional marker routinely available and monthly determined in HD patients.
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Authors | Nathalie Terrier, Isabelle Jaussent, Anne-Marie Dupuy, Marion Morena, Cécile Delcourt, Lotfi Chalabi, Catherine Rouanet, Bernard Canaud, Jean-Paul Cristol |
Journal | Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
(Nephrol Dial Transplant)
Vol. 23
Issue 1
Pg. 345-53
(Jan 2008)
ISSN: 0931-0509 [Print] England |
PMID | 17890748
(Publication Type: Journal Article)
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Chemical References |
- Biomarkers
- Prealbumin
- Creatinine
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Biomarkers
(blood)
- Cardiovascular Diseases
(blood, etiology, mortality)
- Creatinine
(blood)
- Female
- Humans
- Kidney Failure, Chronic
(blood, complications, therapy)
- Male
- Middle Aged
- Multivariate Analysis
- Prealbumin
(analysis)
- Predictive Value of Tests
- Prognosis
- Renal Dialysis
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