Abstract | AIM: METHODS: RESULTS: Following Caiapo, we observed an increase in OGIS (293 +/- 15 vs. 321 +/- 12 ml/m(2)/min, p = 0.0072) and adiponectin (5.97 +/- 0.65 to 6.63 +/- 0.70 microg/ml, p = 0.013), while fibrinogen decreased from 3.83 +/- 0.16 to 3.64 +/- 0.18 mg/ml (p = 0.02). This was associated with an improvement in glycated haemoglobin (HbA1c: 6.46 +/- 0.12 vs. 6.25 +/- 0.11%, p = 0.008), fasting glucose (138 +/- 4 vs. 128 +/- 5 mg/dl, p = 0.039) and triglycerides (2.36 +/- 0.22 vs. 2.07 +/- 0.25 mmol/l, p = 0.032). Body weight, lipid levels and hs-CRP were not altered. No changes were observed in the placebo group except for HbA1c, which significantly increased from 6.25 +/- 0.10 to 6.50 +/- 0.12% (p = 0.0001). CONCLUSIONS: This study confirms the beneficial effects of Caiapo on glucose and HbA1c control in patients with T2DM after 5 months follow-up. Improvement of insulin sensitivity was accompanied by increased levels of adiponectin and a decrease in fibrinogen. Thus, Caiapo can be considered as natural insulin sensitizer with potential antiatherogenic properties.
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Authors | B Ludvik, M Hanefeld, G Pacini |
Journal | Diabetes, obesity & metabolism
(Diabetes Obes Metab)
Vol. 10
Issue 7
Pg. 586-92
(Jul 2008)
ISSN: 1463-1326 [Electronic] England |
PMID | 17645559
(Publication Type: Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Adiponectin
- Blood Glucose
- Glycated Hemoglobin A
- Insulin
- Fibrinogen
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Topics |
- Adiponectin
(blood)
- Blood Glucose
(metabolism)
- Diabetes Mellitus, Type 2
(blood, drug therapy)
- Female
- Fibrinogen
(metabolism)
- Glucose Tolerance Test
- Glycated Hemoglobin
(metabolism)
- Humans
- Insulin
(blood)
- Ipomoea batatas
- Male
- Middle Aged
- Phytotherapy
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