Effects of soluble fiber (Plantago ovata husk) on plasma lipids, lipoproteins, and apolipoproteins in men with ischemic heart disease.

Abstract

BACKGROUND:

New dietary strategies to reduce cardiovascular disease (CVD) risk include the addition of fiber to the diet. The effect of soluble-fiber consumption derived from Plantago ovata husk on lipid risk factors in patients with CVD is unknown.

OBJECTIVE:

We compared the effects of soluble fiber (P. ovata husk) with those of insoluble fiber (P. ovata seeds) on plasma lipid, lipoprotein, and apolipoprotein (apo) concentrations within a CVD secondary prevention program.

DESIGN:

In a randomized, crossover, controlled, single-blind design, 28 men with CVD (myocardial infarction or stable angina) and an LDL-cholesterol concentration </=3.35 mmol/L consumed for 8 wk, under controlled conditions, a low-saturated-fat diet supplemented with 10.5 g P. ovata husk/d or 10.5 g P. ovata seeds/d. Fasting plasma lipid concentrations and polymorphisms of genes involved in lipid metabolism, such as apo A-IV, apo E, and fatty acid-binding protein, were measured.

RESULTS:

Plasma triacylglycerol decreased (6.7%; P < 0.02), the ratio of apo B 100 to apo A-I decreased (4.7%; P < 0.02), and apo A-I increased (4.3%; P < 0.01) in the P. ovata husk consumers. Compared with the intake of insoluble fiber, the intake of P. ovata husk increased HDL-cholesterol concentrations by 6.7% (P = 0.006) and decreased the ratio of total to HDL cholesterol and of LDL to HDL cholesterol by 10.6% (P = 0.002) and 14.2% (P = 0.003), respectively.

CONCLUSION:

In the secondary prevention of CVD, P. ovata husk intake induces a more beneficial effect on the cardiovascular lipid risk-factor profile than does an equivalent intake of insoluble fiber.

• Authors: Rosa Solà, Gemma Godàs, Josep Ribalta, Joan-Carles Vallvé, Josefa Girona, Anna Anguera, Maadoracion Ostos, Delia Recalde, Juliana Salazar, Muriel Caslake, Francisco Martín-Luján, Jordi Salas-Salvadó, Lluís Masana
• Journal: The American journal of clinical nutrition (Am J Clin Nutr) Vol. 85 Issue 4 Pg. 1157-63 (Apr 2007) ISSN: 0002-9165 [Print] United States
• PMID: 17413119 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Apolipoproteins
• Dietary Fiber
• Lipids
• Lipoproteins

Topics

• Angina Pectoris (blood, diet therapy, genetics)
• Apolipoproteins (blood)
• Cross-Over Studies
• Dietary Fiber (administration & dosage, pharmacology)
• Genotype
• Humans
• Lipids (blood)
• Lipoproteins (blood)
• Male
• Middle Aged
• Myocardial Infarction (blood, diet therapy, genetics)
• Myocardial Ischemia (blood, diet therapy, genetics)
• Patient Compliance
• Plantago
• Single-Blind Method
• Solubility