Abstract | BACKGROUND: METHODS: Nineteen subjects with CD (8 female, 11 male patients) were recruited between April 2003 and June 2004. After an overnight fast, serum iron and hemoglobin levels, serum markers of inflammation [IL-6, C-reactive protein (CRP), and erythrocyte sedimentation rate], and a urine sample for hepcidin assay were obtained at 8 am. Ferrous sulfate (1 mg/kg) was administered orally, followed by determination of serum iron concentrations hourly for 4 hours after the ingestion of iron. An area under the curve for iron absorption was calculated for each patient data set. RESULTS: There was a strong inverse correlation between the area under the curve and IL-6 (P = 0.002) and area under the curve and CRP levels (P = 0.04). Similarly, the difference between baseline and 2-hour serum iron level (Delta[Fe]2hr) correlated with IL-6 (P = 0.008) and CRP (P = 0.045). When cutoff values for IL-6 (>5 pg/mL) and CRP (>1.0 mg/dL) were used, urine hepcidin levels also positively correlated with IL-6 and CRP levels (P = 0.003 and 0.007, respectively). CONCLUSIONS: Subjects with active CD have impaired oral iron absorption and elevated IL-6 levels compared with subjects with inactive disease. These findings suggest that oral iron may be of limited benefit to these patients. Future study is needed to define the molecular basis for impaired iron absorption.
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Authors | Gaith Semrin, Douglas S Fishman, Athos Bousvaros, Anna Zholudev, Andrew C Saunders, Catherine E Correia, Elizabeta Nemeth, Richard J Grand, David A Weinstein |
Journal | Inflammatory bowel diseases
(Inflamm Bowel Dis)
Vol. 12
Issue 12
Pg. 1101-6
(Dec 2006)
ISSN: 1078-0998 [Print] England |
PMID | 17119383
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Chemical References |
- Biomarkers
- Cytokines
- Iron
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Topics |
- Adolescent
- Adult
- Biomarkers
(analysis)
- Child
- Crohn Disease
(metabolism, pathology)
- Cytokines
(blood)
- Demography
- Female
- Humans
- Inflammation
(metabolism)
- Intestinal Absorption
(physiology)
- Iron
(blood, metabolism)
- Malabsorption Syndromes
(pathology)
- Male
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