Pro12Ala polymorphism of the PPARG2 gene is associated with type 2 diabetes mellitus and peripheral insulin sensitivity in a population with a high intake of oleic acid.

Abstract

Activation of the PPAR gamma 2 gene (PPARG2) improves the action of insulin and its lipid metabolism. We examined the association between Pro12Ala polymorphism of PPARG2, type 2 diabetes mellitus (DM2), and peripheral insulin sensitivity in a population with a high intake of oleic acid. A cross-sectional, population-based study was undertaken in Pizarra, a small town in the province of Malaga in southern Spain. A total of 538 subjects, aged 18-65 y, were selected randomly from the municipal census. All subjects underwent a clinical, anthropometrical, and biochemical evaluation, including an oral glucose tolerance test and Pro12Ala polymorphism of PPARG2. Insulin resistance was measured by homeostasis model assessment. Those subjects with the Ala-12 allele had an odds ratio for impaired fasting glucose of 0.55, for impaired glucose tolerance of 0.59, and for DM2 of 0.30. The intake of monounsaturated fatty acids (MUFA) contributed to the variance of the homeostasis model assessment insulin resistance index (HOMA IR) (P = 0.04), with a 2-way interaction between the Ala-12 allele of PPARG2 and the intake of MUFA (P = 0.005). The results suggest the existence of an interaction between Pro12Ala polymorphism of PPARG2 and dietary MUFA, such that obese people with the Ala-12 allele have higher HOMA IR values, especially if their intake of MUFA is low.

• Authors: Federico Soriguer, Sonsoles Morcillo, Fernando Cardona, Gemma Rojo-Martínez, María de la Cruz Almaráz, María de la Soledad Ruiz de Adana, Gabriel Olveira, Francisco Tinahones, Isabel Esteva
• Journal: The Journal of nutrition (J Nutr) Vol. 136 Issue 9 Pg. 2325-30 (Sep 2006) ISSN: 0022-3166 [Print] United States
• PMID: 16920849 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Dietary Fats, Unsaturated
• Fatty Acids, Monounsaturated
• Olive Oil
• PPAR gamma
• Plant Oils
• Oleic Acid
• Alanine

Topics

• Adolescent
• Adult
• Aged
• Alanine (genetics)
• Alleles
• Body Mass Index
• Cross-Sectional Studies
• Diabetes Mellitus, Type 2 (genetics)
• Dietary Fats, Unsaturated (administration & dosage)
• Energy Intake
• Fatty Acids, Monounsaturated (administration & dosage)
• Glucose Tolerance Test
• Homeostasis
• Humans
• Insulin Resistance (genetics)
• Logistic Models
• Middle Aged
• Obesity (genetics)
• Odds Ratio
• Oleic Acid (administration & dosage)
• Olive Oil
• PPAR gamma (genetics)
• Plant Oils (administration & dosage)
• Polymorphism, Genetic
• Spain