TGF-beta1 gene polymorphisms in periodontal diseases.

Abstract

BACKGROUND:

Genetic polymorphisms in the TGF-beta1 gene were shown to interfere with the transcriptional activity of the TGF-beta1 gene, and this influences the production, secretion or activity of the TGF-beta1 growth factor. Transforming growth factor-beta1 (TGF-beta1) gene polymorphism is associated with risk of inflammatory diseases.

OBJECTIVES:

The aim of this study was to evaluate TGF-beta1 gene polymorphisms in a Turkish population with different periodontal diseases and to investigate the association between TGF-beta1 genotype and clinical periodontal parameters.

METHODS:

A total of 134 subjects were included in this study. Genomic DNA was isolated from 51 patients with chronic periodontitis (CP), 43 with generalized aggressive periodontitis (G-AgP) and 40 healthy controls. Three TGF-beta1 gene polymorphisms were identified by PCR-RFLP and MS-PCR at positions +915G/C, Thr263Ile and 713/8delC. Probing pocket depth (PPD), clinical attachment loss (CAL), plaque accumulation (plaque %) and bleeding of probing were obtained. Chi-square, Mann-Whitney U test and logistic regression analysis were used.

RESULTS:

There was a slightly significant difference in +915C positive genotype distributions between CP and control groups (OR: 2.46, CI: 1.010-6.005, p = 0.047). No significant differences were present between G-AgP and controls in +915C positive genotype. Thr263Ile and -713/8delC genotype distributions were not different between study groups. There were significant differences in PPD and CAL scores between +915C positive and negative CP patients.

CONCLUSION:

These findings suggest that the TGF-beta1 (+915C) polymorphic allele might be associated with chronic periodontitis in the Turkish population.

• Authors: Gül Atilla, Gülnur Emingil, Timur Köse, Afig Berdeli
• Journal: Clinical biochemistry (Clin Biochem) Vol. 39 Issue 9 Pg. 929-34 (Sep 2006) ISSN: 0009-9120 [Print] United States
• PMID: 16824504 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Transforming Growth Factor beta

Topics

• Adult
• Alleles
• Chronic Disease
• Female
• Gene Frequency
• Humans
• Male
• Middle Aged
• Periodontal Diseases (genetics)
• Periodontitis (genetics)
• Polymorphism, Genetic
• Regression Analysis
• Transforming Growth Factor beta (genetics)
• Turkey