Chitosan hydrogel as a drug delivery carrier to control angiogenesis.

Abstract

An aqueous solution of photocrosslinkable chitosan containing azide groups and lactose moieties (Az-CH-LA) incorporating paclitaxel formed an insoluble hydrogel within 30 s of ultraviolet light (UV) irradiation. The chitosan hydrogel showed strong potential for use as a new tissue adhesive in surgical applications and wound dressing. The fibroblast growth factor (FGF)-2 molecules retained in the chitosan hydrogel and in an injectable chitosan/IO(4)-heparin hydrogel remain biologically active, and were gradually released from the hydrogels as they biodegraded in vivo. The controlled release of biologically active FGF-2 molecules from the hydrogels caused induction of angiogenesis and collateral circulation occurred in healing-impaired diabetic (db/db) mice and in the ischemic limbs of rats. Paclitaxel, which is an antitumor reagent, was also retained in the chitosan hydrogel and remained biologically active as it was released on degradation of the hydrogel in vivo. The chitosan hydrogels incorporating paclitaxel effectively inhibited tumor growth and angiogenesis in mice. The purpose of this review is to describe the effectiveness of chitosan hydrogel as a local drug delivery carrier for agents (e.g., FGF-2 and paclitaxel) to control angiogenesis. It is thus proposed that chitosan hydrogel may be a promising new local carrier for drugs such as FGF-2 and paclitaxel to control vascularization.

• Authors: Masayuki Ishihara, Kiyohaya Obara, Singo Nakamura, Masanori Fujita, Kazunori Masuoka, Yasuhiro Kanatani, Bonpei Takase, Hidemi Hattori, Yuji Morimoto, Miya Ishihara, Tadaaki Maehara, Makoto Kikuchi
• Journal: Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs (J Artif Organs) Vol. 9 Issue 1 Pg. 8-16 ( 2006) ISSN: 1434-7229 [Print] Japan
• PMID: 16614797 (Publication Type: Journal Article, Review)

Chemical References

• Biocompatible Materials
• Cross-Linking Reagents
• Hydrogels
• Fibroblast Growth Factor 2
• Chitosan
• Paclitaxel

Topics

• Animals
• Biocompatible Materials
• Chitosan (chemistry)
• Cross-Linking Reagents
• Drug Delivery Systems
• Fibroblast Growth Factor 2 (administration & dosage, pharmacology)
• Hydrogels (chemistry)
• Mice
• Mice, Inbred Strains
• Neovascularization, Pathologic (prevention & control)
• Occlusive Dressings
• Paclitaxel (administration & dosage, pharmacology)
• Rabbits
• Ultraviolet Rays
• Wound Healing (physiology)