Abstract | BACKGROUND AND AIM: Hematopoietic cytokines (HCs) regulate the proliferation and differentiation of hematopoietic progenitor cells, and it was proved that HCs can promote cancer growth. The aim of this study is to determine whether HCs might be useful in the diagnosis of colorectal cancer. MATERIALS AND METHODS: RESULTS: Serum levels of GM-CSF, M-CSF, and tumor markers were significantly higher in cancer patients as compared to the control group and adenomas patients. Of these, hematopoietic cytokines were found elevated in the higher proportion of patients than CEA and CA 19-9. The sensitivity of SCF was higher than the sensitivity of other cytokines, but diagnostic specificity and predictive value were highest for M-CSF. Moreover, the M-CSF area under the receiver operating characteristic curve was larger than the areas of other cytokines. The highest values of diagnostic parameters were observed for the combined use of M-CSF with CEA. CONCLUSION:
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Authors | Barbara Mroczko, Maciej Szmitkowski, Urszula Wereszczyńska-Siemiatkowska, Bogna Okulczyk, Bogusław Kedra |
Journal | International journal of colorectal disease
(Int J Colorectal Dis)
Vol. 22
Issue 1
Pg. 33-8
(Jan 2007)
ISSN: 0179-1958 [Print] Germany |
PMID | 16520929
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Biomarkers, Tumor
- Hematopoietic Cell Growth Factors
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Topics |
- Adenoma
(blood, diagnosis, therapy)
- Adult
- Aged
- Aged, 80 and over
- Biomarkers, Tumor
(blood)
- Colorectal Neoplasms
(blood, diagnosis, therapy)
- Diagnosis, Differential
- Enzyme-Linked Immunosorbent Assay
- Female
- Hematopoietic Cell Growth Factors
(blood)
- Humans
- Male
- Middle Aged
- Sensitivity and Specificity
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