Plasma concentrations of adhesion molecules and chemokines in patients with essential hypertension.

Abstract

Arterial hypertension vascular injury results in serious complications, such as left-ventricular hypertrophy and myocardial failure, ischemic heart disease and cerebral stroke. Currently, it is well known that inflammatory factors play a significant role in the mechanisms that trigger and enhance the remodeling of the vascular wall. A number of data suggest an important role of adhesion molecules and chemokines in this processes. The aim of this study was measuring the plasma levels of soluble Intercellular Adhesion Molecule 1 (sICAM-1) and Monocyte Chemoattractant Peptide1 (MCP-1) in patients with essential hypertension vs. healthy volunteers by ELISA method (R&D kits). sICAM-1 and MCP-1 levels were significantly higher in hypertensive patients compared to controls (sICAM-1: 279.2 +/- 8.8 ng/ml vs. 224.4 +/- 1.8 ng/ml; p < 0.001; MCP-1: 142.2 +/- 7 pg/ml vs. 95.4 +/- 36 pg/ml; p < 0.0001. Our results indicate that arterial hypertension alone (without inflammation, lipid and carbohydrate disorders) may increase the expression of these cytokines and contribute to the progression of endothelial injury.

• Authors: Andrzej Madej, Bogusław Okopień, Jan Kowalski, Maciej Haberka, Zbigniew S Herman
• Journal: Pharmacological reports : PR (Pharmacol Rep) 2005 Nov-Dec Vol. 57 Issue 6 Pg. 878-81 ISSN: 1734-1140 [Print] Switzerland
• PMID: 16382212 (Publication Type: Comparative Study, Journal Article)

Chemical References

• CCL2 protein, human
• Chemokine CCL2
• Lipids
• Intercellular Adhesion Molecule-1

Topics

• Adult
• Chemokine CCL2 (blood)
• Female
• Humans
• Hypertension (blood)
• Intercellular Adhesion Molecule-1 (blood)
• Lipids (blood)
• Male
• Middle Aged