Abstract | BACKGROUND: METHODS: RESULTS: Pigs from the CHOL group showed significant endothelial dysfunction in the LCx territory. The dysfunction was normalized partially by L-arginine supplementation, which restored the response in the LCx territory to the level of the nonischemic anterior wall. L-arginine supplementation resulted in increases of perfusion, density of capillary endothelial, and level of endothelial nitric oxide synthase in the ischemic region. Despite these findings, no improvement in myocardial regional function was found. CONCLUSIONS:
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Authors | Yasunari Nakai, Pierre Voisine, Cesario Bianchi, Shu-Hua Xu, Jun Feng, Tamer Malik, Audrey Rosinberg, Frank W Sellke |
Journal | Surgery
(Surgery)
Vol. 138
Issue 2
Pg. 291-8
(Aug 2005)
ISSN: 0039-6060 [Print] United States |
PMID | 16153439
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Arginine
- Cholesterol
- Nitric Oxide Synthase
- Nitric Oxide Synthase Type II
- Nitric Oxide Synthase Type III
|
Topics |
- Animals
- Arginine
(pharmacology)
- Blotting, Western
- Cholesterol
(blood)
- Coronary Artery Disease
(drug therapy, physiopathology)
- Coronary Circulation
(drug effects)
- Disease Models, Animal
- Hypercholesterolemia
(drug therapy, physiopathology)
- Microcirculation
(drug effects)
- Myocardial Contraction
- Neovascularization, Physiologic
(drug effects)
- Nitric Oxide Synthase
(metabolism)
- Nitric Oxide Synthase Type II
- Nitric Oxide Synthase Type III
- Swine
- Swine, Miniature
- Vasodilation
(drug effects)
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