Abstract | OBJECTIVES: METHODS: RESULTS: Haematopoietic reconstitution was rapid and sustained. Toxicity due to the regimen included various infections such as pneumonia, sepsis, cystitis, herpes zoster, and acute heart failure. However, there was no treatment related mortality. Encouraging results were obtained after autologous PBSCT. Sclerosis of the skin was markedly improved in all of the patients with SSc. Interstitial pneumonia (IP), evaluated by PaO2, serum KL-6 levels, and pulmonary high resolution computed tomography, improved significantly. In a patient with ADM, severe and progressive IP also improved markedly. In a patient with WG, the size of the left orbital granuloma decreased substantially, resulting in reduction of the exophthalmos. CONCLUSIONS: These observations suggest that high dose CY with autologous PBSCT is feasible and may be effective in the treatment of severe and refractory AD.
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Authors | H Tsukamoto, K Nagafuji, T Horiuchi, T Miyamoto, K Aoki, K Takase, H Henzan, D Himeji, T Koyama, K Miyake, Y Inoue, H Nakashima, T Otsuka, Y Tanaka, K Nagasawa, M Harada |
Journal | Annals of the rheumatic diseases
(Ann Rheum Dis)
Vol. 65
Issue 4
Pg. 508-14
(Apr 2006)
ISSN: 0003-4967 [Print] England |
PMID | 16126798
(Publication Type: Clinical Trial, Phase I, Clinical Trial, Phase II, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antigens, CD34
- Immunosuppressive Agents
- Cyclophosphamide
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Topics |
- Adult
- Antigens, CD34
(blood)
- Autoimmune Diseases
(therapy)
- Combined Modality Therapy
- Cyclophosphamide
(adverse effects, therapeutic use)
- Dermatomyositis
(therapy)
- Feasibility Studies
- Female
- Granulomatosis with Polyangiitis
(therapy)
- Hematopoietic Stem Cell Mobilization
(methods)
- Humans
- Immunomagnetic Separation
(methods)
- Immunosuppressive Agents
(adverse effects, therapeutic use)
- Male
- Middle Aged
- Opportunistic Infections
(etiology)
- Peripheral Blood Stem Cell Transplantation
(adverse effects)
- Scleroderma, Systemic
(therapy)
- Treatment Outcome
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