Exposure to bisphenol A is associated with recurrent miscarriage.

Abstract

BACKGROUND:

Little is known about the influence of high exposure to bisphenol A on recurrent miscarriage and immunoendocrine abnormalities.

METHODS:

Serum bisphenol A, antiphospholipid antibodies (aPLs), antinuclear antibodies (ANAs), natural killer cell (NK) activity, prolactin, progesterone, thyroid-stimulating hormone (TSH) and free T4 were examined in 45 patients with a history of three or more (3-11) consecutive first-trimester miscarriages and 32 healthy women with no history of live birth and infertility. Subsequent pregnancy outcome and embryonic karyotype of abortuses were examined prospectively.

RESULTS:

The mean+/-SD values for bisphenol A in patients were 2.59+/-5.23 ng/ml, significantly higher than the 0.77+/-0.38 ng/ml found for control women (P=0.024). High exposure to bisphenol A was associated with the presence of ANAs but not hypothyroidism, hyperprolactinaemia, luteal phase defects, NK cell activity or aPLs. A high level of bisphenol A in itself did not predict subsequent miscarriage.

CONCLUSION:

Exposure to bisphenol A is associated with recurrent miscarriage.

• Authors: Mayumi Sugiura-Ogasawara, Yasuhiko Ozaki, Shin-ichi Sonta, Tsunehisa Makino, Kaoru Suzumori
• Journal: Human reproduction (Oxford, England) (Hum Reprod) Vol. 20 Issue 8 Pg. 2325-9 (Aug 2005) ISSN: 0268-1161 [Print] England
• PMID: 15947000 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antibodies, Antinuclear
• Antibodies, Antiphospholipid
• Benzhydryl Compounds
• Estrogens, Non-Steroidal
• Phenols
• Progesterone
• Prolactin
• Thyrotropin
• bisphenol A
• Thyroxine

Topics

• Abortion, Habitual (blood, chemically induced, immunology)
• Adult
• Antibodies, Antinuclear (blood)
• Antibodies, Antiphospholipid (blood)
• Benzhydryl Compounds
• Environmental Exposure
• Estrogens, Non-Steroidal (adverse effects, blood)
• Female
• Humans
• Killer Cells, Natural (immunology)
• Phenols (adverse effects, blood)
• Pregnancy
• Progesterone (blood)
• Prolactin (blood)
• Thyrotropin (blood)
• Thyroxine (blood)