Peroxisome proliferator-activated receptors gamma ligands and ischemia and reperfusion injury.

Abstract

Peroxisome proliferator-activated receptors (PPARs) are members of the nuclear hormone receptor superfamily of ligand-activated transcription factors that are related to retinoid, steroid and thyroid hormone receptors. The PPAR subfamily comprises of three members, PPAR-alpha, PPAR-beta and PPAR-gamma. PPAR-gamma has recently been implicated as a regulator of cellular proliferation and inflammatory responses. There is good evidence that ligands of PPAR-gamma, including certain thiazolinediones, reduce tissue injury associated with ischemia and reperfusion. The potential utility of PPAR-gamma ligands in ischemia and reperfusion will be discussed in this review.

• Authors: Salvatore Cuzzocrea
• Journal: Vascular pharmacology (Vascul Pharmacol) Vol. 41 Issue 6 Pg. 187-95 (Jul 2004) ISSN: 1537-1891 [Print] United States
• PMID: 15653094 (Publication Type: Journal Article, Review)

Chemical References

• Ligands
• PPAR gamma

Topics

• Animals
• Humans
• Intestinal Diseases (metabolism)
• Ischemia (metabolism)
• Kidney Diseases (metabolism)
• Ligands
• Lung Diseases (metabolism)
• Myocardial Infarction (metabolism)
• Necrosis (metabolism)
• PPAR gamma (metabolism)
• Reperfusion Injury (metabolism)