HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

The relationship of sex hormones and cortisol with cognitive functioning in Schizophrenia.

Abstract
Gonadal as well as stress hormones have recently been implicated in pathophysiology and sex differences in onset, prognosis and treatment of schizophrenia. The present study investigated the effects of serum levels of oestrogen, progesterone, testosterone and cortisol on neuropsychological functioning and psychopathology in a group of 37 patients (17 women, 20 men) with schizophrenia. Neuropsychological measures included tests of attention, verbal abilities, language, memory, executive functioning, motor and speed of information processing. The results showed that oestrogen and age was associated with low positive symptom scores, and within gender, cortisol predicted poor performance on the information processing domain in men. These findings demonstrate that cortisol, in addition to the commonly reported effects of oestrogen, influences neuropsychological functioning in schizophrenia with differential effects on specific domains of cognitive functioning and underscore the need for further investigation of the modulating role of hormones on neuropsychological functioning in schizophrenia.
AuthorsR Halari, V Kumari, R Mehrotra, M Wheeler, M Hines, T Sharma
JournalJournal of psychopharmacology (Oxford, England) (J Psychopharmacol) Vol. 18 Issue 3 Pg. 366-74 (Sep 2004) ISSN: 0269-8811 [Print] United States
PMID15358980 (Publication Type: Clinical Trial, Comparative Study, Journal Article)
Chemical References
  • Gonadal Steroid Hormones
  • Testosterone
  • Progesterone
  • Estradiol
  • Prolactin
  • Luteinizing Hormone
  • Follicle Stimulating Hormone
  • Hydrocortisone
Topics
  • Adolescent
  • Adult
  • Age Factors
  • Cognition
  • Estradiol (blood)
  • Female
  • Follicle Stimulating Hormone (blood)
  • Gonadal Steroid Hormones (blood)
  • Humans
  • Hydrocortisone (blood)
  • Luteinizing Hormone (blood)
  • Male
  • Middle Aged
  • Neuropsychological Tests
  • Progesterone (blood)
  • Prolactin (blood)
  • Psychomotor Performance
  • Schizophrenic Psychology
  • Sex Factors
  • Testosterone (blood)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: