Abstract | OBJECTIVE: DESIGN: Prospective, randomized, controlled experiment. SETTING: Animal basic science laboratory. SUBJECTS: Male Wistar rats, weighing 300-350 g. INTERVENTIONS: Rats subjected to CLP were treated with either N-acetylcysteine (20 mg/kg, 3 hrs, 6 hrs, 12 hrs, 18 hrs, and 24 hrs after CLP, subcutaneously) plus deferoxamine (20 mg/kg, 3 hrs and 24 hrs after CLP, subcutaneously) or vehicle with or without "basic support" (saline at 50 mL/kg immediately and 12 hrs after CLP plus ceftriaxone at 30 mg/kg and clindamycin 25 mg/kg every 6 hrs). MEASUREMENTS AND MAIN RESULTS: CONCLUSIONS:
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Authors | Cristiane Ritter, Michael E Andrades, Adalisa Reinke, Sérgio Menna-Barreto, José Cláudio F Moreira, Felipe Dal-Pizzol |
Journal | Critical care medicine
(Crit Care Med)
Vol. 32
Issue 2
Pg. 342-9
(Feb 2004)
ISSN: 0090-3493 [Print] United States |
PMID | 14758146
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Free Radical Scavengers
- Iron Chelating Agents
- Deferoxamine
- Acetylcysteine
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Topics |
- Acetylcysteine
(administration & dosage, pharmacology)
- Animals
- Deferoxamine
(administration & dosage, pharmacology)
- Drug Therapy, Combination
- Free Radical Scavengers
(administration & dosage, pharmacology)
- Iron Chelating Agents
(administration & dosage, pharmacology)
- Male
- Oxidative Stress
(drug effects)
- Prospective Studies
- Random Allocation
- Rats
- Rats, Wistar
- Survival Rate
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