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Clindamycin (Cleocin)

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An antibacterial agent that is a semisynthetic analog of LINCOMYCIN.

Also Known As:

Cleocin; 7-Chloro-7-deoxylincomycin; Chlolincocin; Chlorlincocin; Clindamycin Hydrochloride; Clindamycin Monohydrochloride; Clindamycin Monohydrochloride, Monohydrate; Dalacin C; 7 Chloro 7 deoxylincomycin; Hydrochloride, Clindamycin; Monohydrate Clindamycin Monohydrochloride; Monohydrochloride, Clindamycin; Monohydrochloride, Monohydrate Clindamycin; L-threo-alpha-D-galacto-Octopyranoside, methyl 7-chloro-6,7,8-trideoxy-6-(((1-methyl-4-propyl-2-pyrrolidinyl)carbonyl)amino)-1-thio-, (2S-trans)-

Networked: 2399 relevant articles (363 outcomes, 345 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Kremsner, Peter G: 7 articles (06/2012 - 03/2004)
2.	Tanghetti, Emil: 7 articles (11/2009 - 03/2006)
3.	Zaoutis, Theoklis E: 6 articles (07/2015 - 06/2009)
4.	Lewis, James S: 6 articles (01/2014 - 01/2005)
5.	Kaplan, Sheldon L: 6 articles (01/2014 - 01/2003)
6.	Issifou, Saadou: 6 articles (06/2007 - 03/2004)
7.	Daum, Robert S: 5 articles (03/2015 - 04/2006)
8.	Feldman, Steven R: 5 articles (06/2014 - 01/2005)
9.	Mason, Edward O: 5 articles (07/2011 - 01/2003)
10.	Del Rosso, James Q: 5 articles (01/2010 - 01/2004)

Related Diseases

1.	Infection 08/01/1999 - "Clindamycin is effective in the treatment of most infections involving anaerobes and gram-positive cocci, but emerging resistance has become a problem in some clinical settings. " 03/01/1977 - "Clindamycin remained effective against most anaerobic bacteria found in infections, although resistance to the drug was found in certain groups, such as Peptococcus and Clostridium species." 03/01/1988 - "We report five patients with colonization or infection of varying severity caused by MRSA who had the organism successfully eradicated by clindamycin. " 02/01/2007 - "Although therapeutic doses of clindamycin have also been shown to be effective against experimental infections and clindamycin has great efficacy against the production of bacterial exoproteins, we recently reported that the level of production of some exoproteins was unchanged or even increased by a subinhibitory dose of clindamycin when it is added upon the initiation of bacterial culture and the treated cultures were analyzed by two-dimensional gel electrophoresis. " 08/01/2004 - "Epidemiological studies have shown that clindamycin is effective in the treatment of deep infections that are caused by GAS. "
2.	Acne Vulgaris 10/01/2009 - "In our pilot clinical study, we have compared the efficacy of TauBr cream with clindamycin gel, one of the most common topical agents used in the treatment of acne. " 08/01/1981 - "Also, more patients who were receiving clindamycin thought their acne improved by week 8 (with significantly higher change-in-acne scores) than did the patients receiving placebo. " 01/01/2010 - "The efficacy of clindamycin in acne treatment has been shown to be sustained for more than 3 decades. " 08/01/1981 - "These results substantiate the clinical impression that topical clindamycin is effective treatment for acne." 08/01/2009 - "Clindamycin-BP 2.5% aqueous gel is an effective and safe once-daily treatment for moderate or severe acne."
3.	Bacterial Vaginosis 08/01/1995 - "Of the 80 patients who were recorded "success" or "improved" at visit 2, 20 (25%) were reported to have a "recurrence" of BV at Visit 3. The meta-analysis on those who were evaluable at Visit 2 and 3 also showed that clindamycin cream 2% was an effective treatment for bacterial vaginosis, and the differences between the clindamycin group and the placebo group were statistically significant. " 11/01/1994 - "Clindamycin eradicated and/or decreased counts of major bacterial vaginosis-associated microflora such as Gardnerella, gram-negative and gram-positive anaerobes, and Mycoplasma hominis; this was correlated with cure in 22 of 24 (92%) women. " 08/01/1995 - "We conclude that a 3 day course of clindamycin 2% cream is an effective, and well tolerated treatment for bacterial vaginosis." 11/01/1994 - "Microbial (and clinical) results support use of clindamycin as effective treatment of bacterial vaginosis." 11/01/1993 - "Intravaginal clindamycin 2% cream appears to be an effective and safe treatment of symptomatic bacterial vaginosis in nonpregnant women."
4.	Endometritis 12/01/1988 - "Treatment of postpartum endometritis has classically been with clindamycin plus an aminoglycoside. " 05/01/1981 - "The levels of clindamycin in the above-mentioned tests state how samples were compared with the minimal inhibitory concentration of the offending anaerobic pathogens in cases of endometritis." 07/01/1984 - "hominis has been strongly linked to postabortal fever and to postpartum fever and endometritis, our results indicate that clindamycin should be evaluated in treatment trials in pregnancy aimed at prevention of M. " 01/03/1981 - "Patients with endometritis or adnexitis usually received clindamycin in combination with an aminopenicillin. " 01/01/2003 - "The objective of the study was to evaluate the efficacy of gentamicin and clindamycin given once daily versus the more common 8-hour dosing regimen for the treatment of postpartum endometritis. "
5.	Abscess 02/01/1991 - "In a staphylococcal subcutaneous abscess model, however, clindamycin was very effective in curing the Staphylococcus aureus abscesses in this system where PMNs were the primary inflammatory cells involved. " 01/01/1984 - "In one study, tubo-ovarian abscess healed significantly better on medical therapy when clindamycin was included in the regimen. " 04/01/2015 - "Methicillin-resistant Staphylococcus aureus grew on culture from 103 abscesses; 16% of those isolates were resistant to clindamycin. " 04/01/2015 - "Historical and laboratory data from patients with abscesses that grew MRSA with and without clindamycin resistance were compared in a multivariate analysis. " 04/01/2015 - "To identify risk factors for clindamycin resistance in acute hand abscesses caused by methicillin-resistant Staphylococcus aureus (MRSA). "

Related Drugs and Biologics

1.	Gentamicins (Gentamicin)
2.	Metronidazole (Metric)
3.	Benzoyl Peroxide
4.	Anti-Bacterial Agents (Antibiotics)
5.	Penicillins (Penicillin)
6.	Cefoxitin (Cefoxitin Sodium)
7.	Tobramycin (Nebcin)
8.	Erythromycin (Erycette)
9.	Ampicillin (Omnipen)
10.	Vancomycin

Related Therapies and Procedures

1.	Tonsillectomy
2.	Dental Scaling
3.	Oral Administration
4.	Cesarean Section (Caesarean Section)
5.	Chemoprevention