Decreased expression of catalase mRNA in thyroid anaplastic carcinoma.

Abstract

BACKGROUND:

A decreased expression of glutathione peroxidase mRNA, an antioxidant enzyme, was previously observed in thyroid anaplastic carcinomas.

METHODS:

To clarify the expression of antioxidant-related enzymes in thyroid anaplastic carcinomas, the expression levels of catalase, copper and zinc superoxide dismutase and manganese superoxide dismutase mRNA in 85 benign and malignant thyroid tissues were measured by means of real-time quantitative reverse transcription-polymerase chain reaction.

RESULTS:

Decreased expression levels of catalase and copper and zinc superoxide dismutase mRNAs, but not manganese mRNA, were observed in five anaplastic carcinomas compared with normal thyroid tissues and differentiated tumors.

CONCLUSION:

These results suggest the possibility that anaplastic carcinoma cells are more likely to suffer damage by oxygen free radicals than normal thyroid cells or differentiated tumor cells.

• Authors: Yukiko Hasegawa, Toru Takano, Akira Miyauchi, Fumio Matsuzuka, Hiroshi Yoshida, Kanji Kuma, Nobuyuki Amino
• Journal: Japanese journal of clinical oncology (Jpn J Clin Oncol) Vol. 33 Issue 1 Pg. 6-9 (Jan 2003) ISSN: 0368-2811 [Print] England
• PMID: 12604716 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• RNA, Messenger
• Copper
• Catalase
• Superoxide Dismutase
• Zinc

Topics

• Adenoma (metabolism)
• Carcinoma (enzymology, metabolism)
• Carcinoma, Papillary (metabolism)
• Catalase (biosynthesis, genetics)
• Copper (metabolism)
• Humans
• RNA, Messenger (biosynthesis)
• Reverse Transcriptase Polymerase Chain Reaction
• Superoxide Dismutase (metabolism)
• Thyroid Neoplasms (enzymology, metabolism)
• Zinc (metabolism)