Abstract | OBJECTIVE: STUDY DESIGN: To further elucidate the relationship between IL-6 and SIADH as well as IL-6 and HPA axis activity, we studied eight previously healthy children (age 6.3 +/- 4.8 [mean +/- SD] years, weight 23.8 +/- 10.5 kg) who--after sustaining head trauma--presented SIADH during hospitalization (for 7.1 +/- 3.8 days) in the pediatric intensive care unit (P-ICU). Routine blood samples were taken twice daily at 08:00 and 20:00 hours. All children but one survived. Measurements included blood and urine osmolality (BlOsm and UrOsm, respectively), serum cortisol (F) and IL-6, plasma ACTH and AVP. Correlations were assessed with linear regression among the areas under the curve (AUC) of BlOsm, UrOsm, ACTH, F, IL-6 and AVP, separately for BlOsm values <280 mOsm ( SIADH phase) and > or = 280 mOsm (non- SIADH phase). RESULTS: During the SIADH phase AVP-AUC correlated positively with IL-6-AUC (r = +0.96, p<0.05), BlOsm-AUC correlated positively with AVP-AUC and F-AUC (r = +0.95 and +0.98, p<0.05, respectively) and F-AUC correlated positively with ACTH-AUC (r = +0.99, p<0.05). During the non- SIADH phase ACTH-AUC correlated positively with BlOsm-AUC (r = +0.96, p<0.05). CONCLUSION:
IL-6 secreted during an aseptic inflammatory state, such as sustaining head trauma with SIADH, is quantitatively correlated to AVP, indicating that this cytokine is directly and/or indirectly involved in the pathogenesis of SIADH.
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Authors | Demetrios Gionis, Ioannis Ilias, Maria Moustaki, Emilia Mantzos, Ioannis Papadatos, Demetrios A Koutras, George Mastorakos |
Journal | Journal of pediatric endocrinology & metabolism : JPEM
(J Pediatr Endocrinol Metab)
Vol. 16
Issue 1
Pg. 49-54
(Jan 2003)
ISSN: 0334-018X [Print] Germany |
PMID | 12585340
(Publication Type: Journal Article)
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Chemical References |
- Interleukin-6
- Arginine Vasopressin
- Adrenocorticotropic Hormone
- Hydrocortisone
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Topics |
- Adrenocorticotropic Hormone
(blood)
- Area Under Curve
- Arginine Vasopressin
(blood)
- Blood
(metabolism)
- Child
- Child, Preschool
- Craniocerebral Trauma
(blood, complications, physiopathology, urine)
- Female
- Humans
- Hydrocortisone
(blood)
- Hypothalamo-Hypophyseal System
(physiopathology)
- Inappropriate ADH Syndrome
(blood, complications, urine)
- Infant
- Interleukin-6
(blood)
- Male
- Osmolar Concentration
- Pituitary-Adrenal System
(physiopathology)
- Urine
(chemistry)
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