Corticotropin-Releasing Hormone

A peptide of about 41 amino acids that stimulates the release of ADRENOCORTICOTROPIC HORMONE. CRH is synthesized by neurons in the PARAVENTRICULAR NUCLEUS of the HYPOTHALAMUS. After being released into the pituitary portal circulation, CRH stimulates the release of ACTH from the PITUITARY GLAND. CRH can also be synthesized in other tissues, such as PLACENTA; ADRENAL MEDULLA; and TESTIS.

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Networked: 1579 relevant articles (25 outcomes, 145 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Theoharides, Theoharis C: 17 articles (02/2015 - 06/2003)
2.	Holsboer, F: 12 articles (11/2015 - 01/2000)
3.	Koob, George F: 11 articles (02/2012 - 12/2004)
4.	Taché, Yvette: 10 articles (01/2015 - 01/2002)
5.	Nemeroff, Charles B: 10 articles (01/2014 - 01/2002)
6.	Chrousos, George P: 9 articles (10/2012 - 02/2002)
7.	Chen, Alon: 8 articles (02/2016 - 01/2004)
8.	Du, Ji-Zeng: 8 articles (03/2015 - 07/2004)
9.	Million, Mulugeta: 8 articles (01/2015 - 01/2002)
10.	Holsboer, Florian: 8 articles (01/2013 - 01/2004)

Related Diseases

1.	Cushing Syndrome 05/22/1986 - "We conclude that the pathophysiologic features of hypercortisolism in depression and Cushing's disease are distinct in each of the disorders and that the ovine corticotropin-releasing hormone stimulation test can be helpful in their differential diagnosis." 05/22/1986 - "The purpose of this study was to evaluate whether the pituitary-adrenal responses to ovine corticotropin-releasing hormone could help to clarify the mechanism of hypercortisolism in depression and in Cushing's disease and to assist in the differential diagnosis of these disorders. " 07/05/1984 - "These studies demonstrate that ectopic secretion of corticotropin-releasing factor is a cause of Cushing's syndrome in human beings. " 06/01/2010 - "3 Tesla magnetic resonance imaging with and without corticotropin releasing hormone stimulation for the detection of microadenomas in Cushing's syndrome." 01/01/2007 - "[The value of corticotropin-releasing hormone (CRH) test for differential diagnosis of Cushing's syndrome]."
2.	Anxiety Disorders (Anxiety Disorder) 01/01/2009 - "The Sheehan Suicidality Tracking Scale was incorporated into a multicenter, randomized, double-blind, placebo-controlled, and active comparator study examining the efficacy of an experimental corticotropin-releasing factor antagonist (BMS-562086) for the treatment of generalized anxiety disorder. " 05/01/2010 - "Multicenter, randomized, double-blind, active comparator and placebo-controlled trial of a corticotropin-releasing factor receptor-1 antagonist in generalized anxiety disorder." 01/01/1993 - "The role of corticotropin-releasing factor in the pathophysiology of affective and anxiety disorders: laboratory and clinical studies." 02/15/2012 - "Faulty regulation of the central extrahypothalamic corticotropin-releasing factor (CRF) expression is associated with stress-related psychopathologies including anxiety disorders and depression. " 06/01/2011 - "Corticotropin-releasing factor (CRF) functions as one of the major mediators of the mammalian stress response and appears to play a key role in the pathophysiology of mood and anxiety disorders. "
3.	Bipolar Disorder (Mania) 11/01/2014 - "The aim of the present study was to investigate the relationship between peripheral levels of corticotropin-releasing hormone (CRH) and interleukin-1β (IL-1β) in individuals with bipolar disorder (BD) with and without suicide risk (SR), and controls. " 04/01/2014 - "Corticotropin-releasing factor (CRF) is implicated in the pathogenesis of bipolar disorder, an illness associated with deficits in prepulse inhibition (PPI) of the acoustic startle response. " 04/01/2005 - "We examined HPA axis function in a pilot study of five patients with rapid-cycling bipolar disorder in both relapse and remission using the dexamethasone/corticotropin releasing hormone (dex/CRH) test. " 11/01/2014 - "Immune dysfunction in bipolar disorder and suicide risk: is there an association between peripheral corticotropin-releasing hormone and interleukin-1β?" 07/01/1999 - "Enhanced corticotropin response to corticotropin-releasing hormone as a predictor of mania in euthymic bipolar patients."
4.	Ischemia 03/17/2008 - "The contribution of corticotropin-releasing hormone (CRH) in the modulation of ischemia-induced cell death in vivo remains unclear. " 01/06/2006 - "Corticotropin-releasing hormone (CRH) has been implicated in ischemia-induced neurotoxicity, due in part to excitatory effects at the hippocampus, and the demonstrated neuroprotective effects of centrally administered, non-specific CRH antagonists. " 07/30/2004 - "The excitatory actions of corticotropin-releasing hormone (CRH) in the brain and the neuroprotective effects of CRH antagonists in models of ischemia suggest a role for this peptide in the cascade of events leading to cellular damage. " 01/01/2004 - "Detrimental role of corticotropin-releasing factor on the decrease of CA1 field potential induced by in vitro ischemia in rat hippocampal slices." 09/11/1995 - "Corticotropin-releasing hormone (CRH) antagonism has neuroprotective effects in models of ischemia. "
5.	Pain (Aches) 04/14/2010 - "Furthermore, pharmacologic inhibition (with a corticotropin-releasing factor 1 receptor antagonist) of pain-related hyperactivity in the basolateral amygdala (BLA), but not central amygdala (CeA), reversed deactivation of mPFC pyramidal cells and improved decision-making deficits. " 04/01/2006 - "This study examines the contribution of central corticotropin-releasing factor (CRF) to pain behavior. " 10/01/1999 - "Corticotropin-releasing-hormone lacks analgesic properties: an experimental study in humans, using non-inflammatory pain." 06/01/2015 - "As locus coeruleus has been involved in pain and stress-related patologies, we tested whether the pain-induced anxiety is a result of the corticotropin-releasing factor released in the locus coeruleus. " 06/01/2015 - "Corticotropin-Releasing Factor Mediates Pain-Induced Anxiety through the ERK1/2 Signaling Cascade in Locus Coeruleus Neurons."

Related Drugs and Biologics

1.	Adrenocorticotropic Hormone (ACTH)
2.	Dexamethasone (Maxidex)
3.	Hydrocortisone (Cortisol)
4.	Neuropeptides
5.	Corticotropin-Releasing Hormone Receptors (Corticotropin Releasing-Hormone Receptor)
6.	Urocortins
7.	Neurotransmitter Agents (Neurotransmitter)
8.	Peptides
9.	Interleukin-1 (Interleukin 1)
10.	N-Methylaspartate (NMDA)

Related Therapies and Procedures

1.	Adrenalectomy
2.	Injections
3.	Blepharoplasty
4.	Electroacupuncture
5.	Intravenous Injections