The dynamics of
antibodies to organ specific and organ nonspecific
antigens in the process of combined immunization with
Grippol, an
influenza polymer subunit vaccine and polycomponent
vaccine VP-4 used for prophylaxis of acute
respiratory infections, was under study. Persons aged 65 years and older were vaccinated.
Grippol alone was introduced in a single
subcutaneous injection into 92 persons and
Grippol in combination with
vaccine VP-4--to 103 persons. B[symbol: see text]-4
Vaccine was introduced intranasally and orally (6-8 doses). The administration of
vaccine VP-4 was started simultaneously with vaccination with
Grippol. Prior to immunization and 1 and 5 months later
autoantibodies to the following
antigens were detected:
DNA (native and denaturated),
collagen,
elastin,
myelin basic protein, microsomal fractions of kidneys, lungs, heart, liver, intestine, pituitary body, thyroid gland, pancreas, adrenal glands, ovaries, mucous and muscular layers of stomach. The number of persons with the level of
antibodies at least to one of the
antigens under study exceeding the normal values prior to vaccination varied from 19.4 +/- 8.6% to 41.5 +/- 7.7%, the average values of positive sera being 0.26 +/- 0.05 to 0.32 +/- 0.08 delta OD. One and 5 months after vaccination both values varied within the same limits in both groups. Immunization with
Grippol as well as with its combination with
vaccine VP-4 was found to increased spectrum of
antibodies to tissue
antigens and their increased content. The data give evidence that
Grippol and
vaccine Vp-4, introduced according to the immunization schedule used in these experiments, do not induce development of autoimmune processes.