Abstract | AIMS/HYPOTHESIS: METHODS: RESULTS: Glomeruli from placebo-treated patients with diabetic nephropathy, showed a 62% reduction in nephrin expression compared with control subjects (p=0.0003). In contrast, nephrin RNA in glomeruli from perindopril treated patients was similar to that in the non-diabetic control group. In both placebo and perindopril treated patients, a close inverse correlation was noted between the magnitude of nephrin gene expression and the degree of proteinuria (placebo: r=0.86, p=0.013, perindopril: r=0.91, p=0.004). CONCLUSION/INTERPRETATION: Modulation in nephrin expression is related to the extent of proteinuria in diabetic nephropathy. These changes define, at a molecular level alterations in the glomerulus that occur in relation to proteinuria in diabetes and the effects of anti-proteinuric treatment with ACE inhibition.
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Authors | R G Langham, D J Kelly, A J Cox, N M Thomson, H Holthöfer, P Zaoui, N Pinel, D J Cordonnier, R E Gilbert |
Journal | Diabetologia
(Diabetologia)
Vol. 45
Issue 11
Pg. 1572-6
(Nov 2002)
ISSN: 0012-186X [Print] Germany |
PMID | 12436341
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Angiotensin-Converting Enzyme Inhibitors
- Glycated Hemoglobin A
- Membrane Proteins
- Placebos
- Proteins
- nephrin
- Creatinine
- Perindopril
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Topics |
- Angiotensin-Converting Enzyme Inhibitors
(therapeutic use)
- Biopsy
- Blood Pressure
(drug effects)
- Creatinine
(metabolism)
- Diabetic Nephropathies
(pathology, physiopathology, urine)
- Gene Expression Regulation
(drug effects)
- Glycated Hemoglobin
(metabolism)
- Humans
- In Situ Hybridization
- Membrane Proteins
- Perindopril
(therapeutic use)
- Placebos
- Proteins
(drug effects, genetics)
- Proteinuria
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