Abstract | BACKGROUND: METHODS: In total, 205 eligible subjects in Study A and 201 in Study B were randomized to receive a single oral dose of valdecoxib (20 or 40 milligrams), a combination of oxycodone 10 mg/ acetaminophen 1,000 mg or placebo. Eligible subjects experienced moderate-to-severe pain within six hours of surgery during which two or more impacted third molars were extracted. Analgesic efficacy was assessed over 24 hours or until the patient required rescue analgesia. RESULTS: CONCLUSIONS: CLINICAL IMPLICATIONS:
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Authors | Stephen E Daniels, Paul J Desjardins, Sheela Talwalker, David P Recker, Kenneth M Verburg |
Journal | Journal of the American Dental Association (1939)
(J Am Dent Assoc)
Vol. 133
Issue 5
Pg. 611-21; quiz 625
(May 2002)
ISSN: 0002-8177 [Print] England |
PMID | 12036167
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Analgesics, Non-Narcotic
- Analgesics, Opioid
- Cyclooxygenase Inhibitors
- Drug Combinations
- Isoxazoles
- Sulfonamides
- valdecoxib
- Acetaminophen
- Oxycodone
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Topics |
- Acetaminophen
(administration & dosage)
- Adult
- Analgesics, Non-Narcotic
(administration & dosage)
- Analgesics, Opioid
(administration & dosage)
- Analysis of Variance
- Consumer Product Safety
- Cyclooxygenase Inhibitors
(administration & dosage)
- Double-Blind Method
- Drug Combinations
- Female
- Humans
- Isoxazoles
(administration & dosage)
- Male
- Molar, Third
(surgery)
- Oxycodone
(administration & dosage)
- Pain, Postoperative
(etiology, prevention & control)
- Sulfonamides
(administration & dosage)
- Tooth Extraction
(adverse effects)
- Tooth, Impacted
(surgery)
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