The effect of fluvastatin of hyperlipidemia in renal transplant recipients: a prospective, placebo-controlled study.

Abstract

Posttransplant hyperlipidemia is a common complication which may affect long term cardiovascular mortality. In this prospective, placebo-controlled study, 19 renal transplant recipients (11 male 8 female, mean age 31.2 +/- 8.4 years) with good allograft function (serum creatinine <2 mg/dl) more than 6 months after transplantation were included. All the patients had hyperlipidemia (serum cholesterol >230 mg/dl and/or LDL-cholesterol >130 mg/dl) despite dietary interventions. The patients were treated with a triple immunosuppressive regimen. After a 8-week period of placebo plus diet regimen, the patients were put on fluvastatin plus diet for another 8 weeks. The patients were followed for its effect on lipid parameters and side effects. After convertion to fluvastatin, serum cholesterol (263.0 +/- 31.6 vs 223.2 +/- 31.6 mg/dl, p = 0.001), LDL-cholesterol (174.4 +/- 28.3 vs 136.4 +/- 28.5 mg/dl, p = 0.002), Apolipoprotein (Apo) A1 (131.1 +/- 16.9 vs 114.7 +/- 18.4 mg/dl, p = 0.001) and Apo B (109.0 +/- 29.8 vs 97.3 +/- 31.5 mg/dl, p = 0.02) levels decreased significantly. Serum levels of triglycerides, VLDL-cholesterol and HDL-cholesterol levels did not vary under fluvastatin. Serum lipoprotein (a) levels were also unchanged during the whole study period (24.9 +/- 19.4 vs 23.1 +/- 19.8 mg/dl, p > 0.05). We concluded that fluvastatin effectively decreased atherogenic lipoproteins such as serum cholesterol, LDL-cholesterol, Apo B in posttransplant hyperlipidemia, however fluvastatin had no effect on another independent risk factor of atherogenesis, serum lipoprotein (a) levels.

• Authors: S Türk, A Yildiz, T Tükek, V Akkaya, U Aras, A Türkmen, A R Uras, M S Sever
• Journal: International urology and nephrology (Int Urol Nephrol) Vol. 32 Issue 4 Pg. 713-6 ( 2001) ISSN: 0301-1623 [Print] Netherlands
• PMID: 11989571 (Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article)

Chemical References

• Anticholesteremic Agents
• Apolipoproteins
• Fatty Acids, Monounsaturated
• Hydroxymethylglutaryl-CoA Reductase Inhibitors
• Indoles
• Lipids
• Lipoprotein(a)
• Lipoproteins, LDL
• Fluvastatin
• Cholesterol

Topics

• Adolescent
• Adult
• Anticholesteremic Agents (therapeutic use)
• Apolipoproteins (blood)
• Cholesterol (blood)
• Fatty Acids, Monounsaturated (therapeutic use)
• Female
• Fluvastatin
• Humans
• Hydroxymethylglutaryl-CoA Reductase Inhibitors (therapeutic use)
• Hyperlipidemias (blood, drug therapy, etiology)
• Indoles (therapeutic use)
• Kidney Transplantation (adverse effects)
• Lipids (blood)
• Lipoprotein(a) (blood)
• Lipoproteins, LDL (blood)
• Male
• Middle Aged
• Prospective Studies
• Treatment Outcome