Interleukin-18 in patients with congestive heart failure: induction of atrial natriuretic peptide gene expression.
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| Abstract |
Activated inflammatory responses appear to play a role in the development of congestive heart failure (CHF). We investigated interleukin-18 (IL-18), which is a cytokine synthesized by activated macrophage, changes in patients with CHF. We evaluated 11 Japanese patients with angina pectoris (n=4) or CHF (n=7). Blood was sampled immediately after admission and at 1, 2, 3, 6, and 9 hours after admission and then every 12 hours until 5 days after admission. Plasma IL-18 concentrations were measured by an enzyme-linked immunosorbent assay. Expression of atrial natriuretic peptide (ANP) mRNA and protein synthesis was examined in cardiac myocyte by stimulation of IL-18. Plasma IL-18 concentration was significantly higher in patients with CHF than in 15 healthy volunteers (51+/-21 pg/mL, and 28+11 pg/mL, respectively, P<0.05). Increased expression of ANP mRNA was demonstrated in IL-18 treated myocytes. Protein synthesis in myocytes was increased by IL-18 in a dose-dependent manner. Increased secretion of IL-18 is induced in patients with CHF and correlates with the severity of myocardial damage and dysfunction.
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| Authors | Y Seta, T Kanda, T Tanaka, M Arai, K Sekiguchi, T Yokoyama, M Kurimoto, J Tamura, M Kurabayashi |
| Journal | Research communications in molecular pathology and pharmacology (Res Commun Mol Pathol Pharmacol) 2000 Jul-Aug Vol. 108 Issue 1-2 Pg. 87-95 ISSN: 1078-0297 [Print] United States |
| PMID | 11758978 (Publication Type: Journal Article) |
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