Abstract | BACKGROUND: Epidemiologic observations have indicated that cigarette smoking decreases the risk of ulcerative colitis, but the modes of action remain anonymous. The present study aimed to investigate the beneficial effects of passive cigarette smoking using an animal colitis model. We hypothesized that the underlying mechanisms may involve immunoregulation of cytokines. METHODS: RESULTS: CONCLUSIONS: The results support the idea that the beneficial effects of passive cigarette smoking in experimental colitis involved immunoregulation of cytokines in colonic tissues.
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Authors | J K Ko, N F Sham, X Guo, C H Cho |
Journal | Journal of investigative medicine : the official publication of the American Federation for Clinical Research
(J Investig Med)
Vol. 49
Issue 1
Pg. 21-9
(Jan 2001)
ISSN: 1081-5589 [Print] England |
PMID | 11217144
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Benzenesulfonates
- Cytokines
- Tobacco Smoke Pollution
- Tumor Necrosis Factor-alpha
- 2,4-dinitrobenzenesulfonic acid
- Cyclosporine
- Pentoxifylline
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Topics |
- Animals
- Benzenesulfonates
(toxicity)
- Colitis, Ulcerative
(chemically induced, immunology, prevention & control)
- Cyclosporine
(pharmacology)
- Cytokines
(metabolism)
- Humans
- Male
- Pentoxifylline
(pharmacology)
- Rats
- Rats, Sprague-Dawley
- Tobacco Smoke Pollution
- Tumor Necrosis Factor-alpha
(antagonists & inhibitors)
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