Cornual Pregnancy

A type of pregnancy in which the EMBRYO IMPLANTATION occurs in the horn of the UTERUS instead of in the uterine cavity, i.e. at the junction of the uterus and one of the FALLOPIAN TUBES.

Also Known As:

Networked: 88 relevant articles (6 outcomes, 2 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Respiratory Distress Syndrome (Acute Respiratory Distress Syndrome)
2.	Incomplete Abortion
3.	Tubal Pregnancy
4.	Ectopic Pregnancy
5.	Heterotopic Pregnancy

Experts

1.	Angioni, Stefano: 2 articles (08/2020 - 03/2009)
2.	Huang, Hongli: 1 article (09/2022)
3.	Li, Jing: 1 article (09/2022)
4.	Liu, Heyu: 1 article (09/2022)
5.	Lu, Jingquan: 1 article (09/2022)
6.	Wang, Renxiao: 1 article (09/2022)
7.	Yang, Yi: 1 article (09/2022)
8.	Galani, A: 1 article (01/2022)
9.	Kolibianakis, E: 1 article (01/2022)
10.	Loukopoulos, T: 1 article (01/2022)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Cornual Pregnancy:

1.	Methotrexate (Mexate)FDA LinkGeneric 01/01/2011 - "Systemic methotrexate administration combined with ultrasound-guided local methotrexate injection into the gestational sac might be considered as the first-line treatment in the management of hemodynamically stable patients having cornual pregnancy even with high beta HCG values and risk of myometrial cystic formation." 12/01/2005 - "The recurrent cornual pregnancy was treated successfully with systemic methotrexate. " 01/01/2003 - "The baby weighed 2.9 kg. Local injection of low-dose methotrexate following aspiration of a cornual pregnancy proved effective in halting the ectopic trophoblasts' growth without adversely affecting a coexistent intrauterine pregnancy. " 01/01/2022 - "Multidose methotrexate treatment of cornual pregnancy after in vitro fertilization: Two case reports." 08/01/2020 - "Laparoscopic management of a cornual pregnancy following failed methotrexate treatment: case report and review of literature."
2.	Dihydrotachysterol (AT 10)IBA 07/01/1991 - "A rare case of severe adult respiratory distress syndrome associated with a Po2 of 9 mm Hg after surgical resection of a cornual pregnancy at 10 weeks' gestation was treated successfully with positive end-expiratory pressure. "
3.	Misoprostol (Cytotec)FDA LinkGeneric 09/01/2022 - "The current study found that oral administration of mifepristone, combined with misoprostol, plus uterine curettage was superior to the other three methods in treatment of unruptured cornual pregnancy. "
4.	Mifepristone (RU 486)FDA Link 09/01/2022 - "The current study found that oral administration of mifepristone, combined with misoprostol, plus uterine curettage was superior to the other three methods in treatment of unruptured cornual pregnancy. "
5.	Potassium ChlorideFDA LinkGeneric 01/01/2005 - "A 22-year-old woman with heterotopic cornual pregnancy was treated with ultrasonographically guided transvaginal injection of potassium chloride into the thorax of ectopic fetus. " 09/01/1993 - "Transvaginal ultrasound (US)-guided aspiration/injection of potassium chloride (KCl) was performed in three cornual pregnancies with alive embryo. " 01/01/2009 - "To discuss a case of heterotopic cornual and tubal pregnancy managed with transvaginal potassium chloride (KCl) injection of cornual pregnancy and laparoscopic operation of tubal pregnancy. " 07/01/2018 - "Treatment of unruptured cornual pregnancies by local injections of methotrexate or potassium chloride under transvaginal ultrasonographic guidance."
6.	Leucovorin (Folinic Acid)FDA Link 01/01/1993 - "This report describes a woman with a cornual pregnancy, documented by laparoscopy and ultrasonography, who was successfully treated with a 1-day high-dose methotrexate regimen and folinic acid rescue. " 01/01/1993 - "Successful treatment of cornual pregnancy with 1-day high-dose methotrexate regimen and folinic acid rescue." 01/01/2022 - "Conservative management of cornual pregnancies applying multidose therapy of methotrexate and leucovorin is a safe treatment when patients are asymptomatic and preserves fertility."
7.	Levonorgestrel (Plan B)FDA LinkGeneric 07/22/2009 - "Yet a cornual pregnancy following the use of a levonorgestrel intrauterine device is a complication which, to our knowledge, has not been described before. " 07/22/2009 - "However, we report, for the first time, a major complication of levonorgestrel intrauterine device: a cornual pregnancy. " 07/22/2009 - "Cornual pregnancy as a complicaton of the use of a levonorgestrel intrauterine device: a case report."
8.	Fibrin Tissue Adhesive (Fibrin Sealant)IBA 10/01/1997 - "Cornual pregnancy successfully treated laparoscopically with fibrin glue hemostasis." 10/01/1997 - "We describe laparoscopic treatment with fibrin glue hemostasis in a woman with cornual pregnancy following salpingectomy. " 10/01/1997 - "Laparoscopy appears to be a safe alternative for patients with early cornual pregnancy, and fibrin glue is useful for achieving hemostasis of oozing myometrial wounds."
9.	Vasopressins (Vasopressin)IBA 01/01/2015 - "Robotic-assisted laparoscopic resection of cornual pregnancy was feasible and was associated with minimal blood loss, aided with the use of an endoscopic vascular clamp and intramural vasopressin."
10.	Proteins (Proteins, Gene)FDA Link 01/01/1990 - "Maternal serum placental protein 12 (PP12) was measured at the time of presentation in 33 women with a histologically confirmed diagnosis of ectopic pregnancy [tubal pregnancy (n = 29), tubal pregnancy with a live fetus (n = 2), cornual pregnancy (n = 1) and ovarian pregnancy (n = 1)]. "

Therapies and Procedures

1.	Laparotomy 09/01/2008 - "Improved laparoscopic technique, accumulated experience, and possibly earlier diagnosis have led to fewer operative failures or need to convert to laparotomy during treatment of cornual pregnancy. " 12/26/2016 - "Laparotomy was performed on vital indication with excision of the ruptured haemorrhagic cornual pregnancy. " 05/01/2012 - "Laparotomy was performed for the excision of the isthmo-cornual pregnancy. " 12/01/2009 - "Despite the recent advances in the ultrasonography, diagnosis of cornual pregnancy still remains elusive; with confirmatory diagnosis usually made during laparotomy. " 01/01/2007 - "Diagnosis by ultrasound scan and per-laparoscopic confirmation, followed by resection of the cornual pregnancy by laparotomy. "
2.	Positive-Pressure Respiration (Positive End-Expiratory Pressure) 07/01/1991 - "A rare case of severe adult respiratory distress syndrome associated with a Po2 of 9 mm Hg after surgical resection of a cornual pregnancy at 10 weeks' gestation was treated successfully with positive end-expiratory pressure. "
3.	Therapeutics 06/01/1998 - "Transvaginal colour and angio Doppler blood flow analysis combined with serial measurement of human chorionic gonadotrophin (HCG) concentration is reported here for the first time to study the local vascularity of a cornual pregnancy and to monitor the effectiveness of medical therapy. " 02/01/2004 - "A very limited number of articles pre have explored the use of intravenous methotrexate to treat cornual pregnancy as a possible conservative first-line therapy in selected, hemodynamically stable patients. " 01/01/2022 - "Conservative management of cornual pregnancies applying multidose therapy of methotrexate and leucovorin is a safe treatment when patients are asymptomatic and preserves fertility."
4.	Curettage 09/01/2022 - "The drug abortion + curettage treatment was found to be a safe, effective, minimally invasive treatment for unruptured cornual pregnancy, which has few side effects and doesn't affect fertility." 11/25/2021 - "Conclusions: Among the patients with cornual pregnancy, multipara, the maximum diameter of lesion<1.5 cm and ultrasound-guided curettage are the risk factors of PEP after operation. " 11/25/2021 - "Among all surgical approaches for cornual pregnancy, the proportion of PEP in curettage under ultrasound monitoring was the highest (56.0%, 14/25), which was higher than that in curettage under laparoscope monitoring (1/10; χ2=6.172，P=0.013); the proportion of PEP in curettage group (42.9%, 15/35) was higher than that in cornuostomy/cornectomy group (4.1%, 3/74; χ2=25.950，P<0.01). " 10/01/2007 - "A case of single large cystic adenomyoma of the uterus (anechoic area 1.6 cm in diameter) was diagnosed by surgery and histopathologic analysis more than 3 years after a transcervical curettage for an early right-cornual pregnancy." 10/01/2007 - "Single large cystic adenomyoma of the uterus after cornual pregnancy and curettage."
5.	Oral Administration 09/01/2022 - "The current study found that oral administration of mifepristone, combined with misoprostol, plus uterine curettage was superior to the other three methods in treatment of unruptured cornual pregnancy. "