Fibrin Tissue Adhesive (Fibrin Sealant)

An autologous or commercial tissue adhesive containing FIBRINOGEN and THROMBIN. The commercial product is a two component system from human plasma that contains more than fibrinogen and thrombin. The first component contains highly concentrated fibrinogen, FACTOR VIII, fibronectin, and traces of other plasma proteins. The second component contains thrombin, calcium chloride, and antifibrinolytic agents such as APROTININ. Mixing of the two components promotes BLOOD CLOTTING and the formation and cross-linking of fibrin. The tissue adhesive is used for tissue sealing, HEMOSTASIS, and WOUND HEALING.

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Networked: 1963 relevant articles (248 outcomes, 317 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Li, Jieshou: 12 articles (04/2015 - 09/2005)
2.	Redl, H: 10 articles (08/2015 - 12/2000)
3.	Ren, Jianan: 9 articles (04/2015 - 09/2005)
4.	Redl, Heinz: 8 articles (01/2014 - 05/2006)
5.	Vaiman, Michael: 8 articles (01/2007 - 04/2002)
6.	Petter-Puchner, A H: 7 articles (08/2015 - 10/2007)
7.	Fortelny, R H: 7 articles (08/2015 - 10/2007)
8.	Wu, Xiuwen: 7 articles (04/2015 - 02/2012)
9.	Petter-Puchner, Alexander H: 7 articles (01/2014 - 12/2005)
10.	Cheng, Henrich: 6 articles (09/2013 - 07/2004)

Related Diseases

1.	Hemorrhage 02/01/1989 - "This study shows that fibrin sealant is safe and highly effective in controlling localized bleeding in cardiac operations. " 08/01/2003 - "These results show that Beriplast is a safe and simple endoscopic treatment option and is very effective in controlling gastric variceal bleeding." 04/01/2010 - "We aimed to verify that diluted fibrin glue can be easily and successfully injected and is effective in the endoscopic treatment of refractory post-ERCP bleeding. " 04/01/1999 - "These results demonstrate the high degree of efficacy of fibrin sealant delivered through a sheath system in plugging liver biopsy tracts and eliminating bleeding in a severely coagulopathic animal model. " 02/01/1995 - "Autologous fibrin tissue adhesive is beneficial in endoscopic sinus surgery, and its application should be considered, especially when the risk of hemorrhage or synechia is increased."
2.	Fistula 03/01/2001 - "Fibrin glue is simple and effective treatment for all anal fistulas with excellent functional results." 12/01/2008 - "Closing the bronchial stump with an appropriate technique and supporting it with fibrin glue were considered effective in preventing bronchopleural fistula development after pulmonary resection in high-risk patients." 12/01/2002 - "Fibrin glue is a novel treatment for anal fistulas and possesses many advantages in the treatment of difficult high fistulas. " 12/20/1996 - "The successful therapy of a suboccipital cerebrospinal fluid fistula by the percutaneous introduction of fibrin glue under computed tomographic guidance is described." 01/01/2009 - "Administration of expanded ASCs (20 to 60 million cells) in combination with fibrin glue is an effective and safe treatment for complex perianal fistula and appears to achieve higher rates of healing than fibrin glue alone."
3.	Wounds and Injuries (Trauma) 09/01/2012 - "In conclusion, suspension of cultured autologous oral keratinocytes in fibrin glue significantly accelerates oral wound healing in the rabbit model and could be beneficial in the treatment of oral wounds in patients." 04/01/1986 - "However, comparisons of the curve magnitudes indicated that there was a significantly greater reduction in wound size in the fibrin sealant treated group. " 05/01/1986 - "This study evaluated Fibrin Sealant (FS), a two-component biologic adhesive that is effective in establishing hemostasis, in 27 experimentally produced splenic injuries in five adult mongrel dogs. " 02/01/1991 - "To prevent postoperative cerebrospinal fluid leakage, the following procedures were very useful; 'blind sack closure' of the external auditory canal, careful closure of the Eustachian tube, use of the pedicled muscle flap from the temporal and the sternocleidomastoid muscle, use of fibrin glue at the time of the wound closure, and placement of preventive spinal drainage. " 05/01/1988 - "The authors believe that fibrin seal is an effective and safe hemostatic agent applicable to splenic parenchymal injuries, and that it promotes wound healing and suppresses adhesion formation."
4.	Pterygium 12/01/2013 - "Pterygium excision with superior or inferior CAU secured with fibrin glue is safe and effective. " 04/01/2013 - "Fibrin glue is effective and safe for attaching conjunctival autograft during pterygium surgery. " 01/01/2015 - "To evaluate the efficacy of conjunctival autograft after the pterygium excision with fibrin adhesive using conjunctiva over the pterygium. " 04/01/2015 - "Autologous blood versus fibrin glue for conjunctival autograft adherence in sutureless pterygium surgery: a randomised controlled trial." 07/01/2014 - "Twenty eyes of 20 participants undergoing pterygium excision with conjunctival autograft secured using human fibrin tissue adhesive were included in the study. "
5.	Seroma 03/01/2006 - "The success rate for seroma resolution (100 percent) was significantly greater with fibrin sealant injection in study patients than with serial aspiration alone (23 percent) in control patients (p = 0.0077). " 10/01/1988 - "At necropsy on day 5, a significant reduction in the frequency of seroma was noted in the fibrin glue group. " 03/01/1997 - "We conclude that (1) the harvesting of the rat latissimus dorsi muscle is a reliable model for creating seromas, (2) fibrin sealant effectively prevents seroma formation when applied intraoperatively, (3) wound healing in the seroma rat model is improved with intraoperative fibrin sealant application, (4) closed injection of fibrin sealant for existing seromas cannot be recommended at this time, (5) virally deactivated fibrin sealant retains its hemostatic and adhesive properties, and (6) current clinical trials of virally deactivated fibrin sealant may facilitate its use in the United States." 12/01/2011 - "Combined quilting and fibrin glue was also effective in reducing the average volume of the seroma and total drained volume of the seroma. " 03/01/2006 - "Percutaneous instillation of fibrin sealant may be an effective treatment for refractory donor-site seromas. "

Related Drugs and Biologics

1.	Fibrin Tissue Adhesive (Fibrin Sealant)
2.	Prostaglandins A (PGA)
3.	Thrombin
4.	Polyglycolic Acid (Polyglycolide)
5.	Fibrinogen (Factor I)
6.	tachocomb
7.	Anti-Bacterial Agents (Antibiotics)
8.	Collagen
9.	Fibrin
10.	polidocanol (Laureth)

Related Therapies and Procedures

1.	Transplants (Transplant)
2.	Sutures (Suture)
3.	Pleurodesis
4.	Absorbable Gelatin Sponge
5.	Gastric Bypass (Roux-en-Y Gastric Bypass)