Catechol O-Methyltransferase Inhibitors

Compounds and drugs that inhibit or block the activity of CATECHOL O-METHYLTRANSFERASE enzymes. Drugs in this class are used in management of central nervous system disorders such as PARKINSON DISEASE.

Also Known As:

Networked: 46 relevant articles (2 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Ishii, Kazuhiro: 2 articles (11/2021 - 11/2021)
2.	Nakamagoe, Kiyotaka: 2 articles (11/2021 - 11/2021)
3.	Tamaoka, Akira: 2 articles (11/2021 - 11/2021)
4.	Tsuji, Hiroshi: 2 articles (11/2021 - 11/2021)
5.	Müller, Thomas: 2 articles (02/2015 - 03/2014)
6.	Clarke, C E: 2 articles (10/2004 - 10/2004)
7.	Deane, K H O: 2 articles (10/2004 - 10/2004)
8.	Spieker, S: 2 articles (10/2004 - 10/2004)
9.	Bonfadini, Janine de Carvalho: 1 article (04/2022)
10.	Braga-Neto, Pedro: 1 article (04/2022)

Related Diseases

1.	Dyskinesias (Dyskinesia) 01/01/2016 - "Mean daily ON time (with no or non-troublesome dyskinesia) and OFF time were favorably changed, compared with placebo, to similar extents regardless of whether patients were receiving concomitant dopamine agonists, catechol-O-methyltransferase inhibitors and amantadine. " 01/01/2017 - "Levodopa still remains the gold standard for the treatment of motor symptoms of PD in advanced stage, but dopamine agonists, monoamine oxidase B inhibitors and catechol-O-methyltransferase inhibitors have--also been developed to provide more continuous oral delivery of dopaminergic stimulation in order to prevent and improve levodopa-induced motor complications, including wearing off phenomenon and peak-dose dyskinesia. " 11/15/1984 - "To reduce peaks and rapid fluctuations of L-DOPA plasma levels (possibly responsible for peak-dose dyskinesias and end-of-dose deterioration) a slow-release formulation of L-DOPA in combination with benserazide or with benserazide plus catechol-O-methyltransferase inhibitors should be developed. " 01/01/2013 - "The aim of the study was to verify whether a combination of levodopa with DOPA decarboxylase and catechol-O-methyltransferase inhibitors (stalevo) could delay the development of dyskinesia compared to the standard two-component drug due to the more stable concentration levodopa in the blood that provided the persistent stimulation of dopamine receptors in the striatum. "
2.	Parkinson Disease (Parkinson's Disease) 01/01/2014 - "The development of new catechol-O-methyltransferase inhibitors has led to an improvement in the treatment of Parkinson's disease. " 01/01/2022 - "COMT (catechol-O-methyltransferase) inhibitors are key therapeutic agents in the management of motor fluctuations (MF) in patients with Parkinson's disease (PD). " 12/31/2021 - "Discovery of Small Molecules as Membrane-Bound Catechol-O-methyltransferase Inhibitors with Interest in Parkinson's Disease: Pharmacophore Modeling, Molecular Docking and In Vitro Experimental Validation Studies." 02/01/2015 - "Catechol-O-methyltransferase inhibitors in Parkinson's disease." 05/01/2003 - "Hepatotoxic profile of catechol-O-methyltransferase inhibitors in Parkinson's disease."
3.	Disease Progression 01/01/2017 - "In younger patients, levodopa should be added to dopamine agonists and/or MAO-B I, as required by disease progression, whereas in older patients, when response to levodopa alone is not satisfactory, dopamine agonists or catechol-O-methyltransferase inhibitors may subsequently be added."
4.	Shwartzman Phenomenon (Shwartzman Reaction) 08/01/1978 - "Sensitization to the generalized Shwartzman reaction by catechol-O-methyltransferase inhibitors."
5.	Schizophrenia (Dementia Praecox) 01/01/2007 - "Treatment of cognitive deficits associated with schizophrenia: potential role of catechol-O-methyltransferase inhibitors."

Related Drugs and Biologics

1.	Levodopa (L Dopa)
2.	Dopamine Agonists (Dopamine Agonist)
3.	Monoamine Oxidase (MAO)
4.	Dopa Decarboxylase
5.	Dopamine Receptors (Dopamine Receptor)
6.	Stalevo
7.	entacapone (Comtan)
8.	Cholinergic Antagonists (Anticholinergics)
9.	Amantadine (Aman)
10.	opicapone

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)
3.	Polypharmacy