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Cholinergic Antagonists (Anticholinergics)

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Drugs that bind to but do not activate CHOLINERGIC RECEPTORS, thereby blocking the actions of ACETYLCHOLINE or cholinergic agonists.

Also Known As:

Anticholinergics; Anticholinergic Agents; Anti-Cholinergics; Cholinergic Antagonist; Agents, Anticholinergic; Agents, Cholinergic-Blocking; Antagonist, Cholinergic; Antagonists, Acetylcholine; Antagonists, Cholinergic; Anti Cholinergics; Cholinergic Blocking Agents; Acetylcholine Antagonists; Cholinergic-Blocking Agents; Cholinolytics

Networked: 1267 relevant articles (116 outcomes, 113 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Chemical Actions and Uses
- Pharmacologic Actions: 56
  - Molecular Mechanisms of Pharmacological Action: 7
    - Neurotransmitter Agents: 7915
      - Cholinergic Agents: 368
        Cholinergic Antagonists: 1267
        Muscarinic Antagonists: 459
        Nicotinic Antagonists: 19
  - Physiological Effects of Drugs: 1
    - Neurotransmitter Agents: 7915
      - Cholinergic Agents: 368
        Cholinergic Antagonists: 1267
        Muscarinic Antagonists: 459
        Nicotinic Antagonists: 19

Experts

1.	Gotoh, Momokazu: 6 articles (11/2011 - 01/2005)
2.	Gosens, Reinoud: 5 articles (01/2015 - 05/2005)
3.	Meurs, Herman: 5 articles (01/2015 - 05/2005)
4.	Haag-Molkenteller, Cornelia: 5 articles (09/2013 - 12/2010)
5.	Dmochowski, Roger: 5 articles (06/2013 - 01/2005)
6.	Aparasu, Rajender R: 4 articles (11/2015 - 12/2010)
7.	Yamanishi, Tomonori: 4 articles (03/2015 - 11/2002)
8.	Hanlon, Joseph T: 4 articles (03/2015 - 10/2009)
9.	Ducharme, Francine M: 4 articles (01/2014 - 01/2003)
10.	Chancellor, Michael B: 4 articles (11/2013 - 05/2007)

Related Diseases

1.	Chronic Obstructive Pulmonary Disease (COPD) 05/03/2011 - "Long-acting inhaled β-agonists and anticholinergics have both been shown to improve COPD outcomes and are recommended for moderate to severe disease; however, little is known about their comparative effectiveness. " 06/01/2004 - "Are beta-2-agonists or anticholinergics more effective for treating COPD?" 12/01/2015 - "A combination of long-acting anticholinergic agents (LAACs) and long-acting β2-adrenergic receptor agonist (LABA) is effective in improving lung function in chronic obstructive pulmonary disease (COPD) compared with monotherapy. " 06/01/2006 - "By the majority, only symptomatic medication is effective for COPD, like anticholinergic agents and beta2-agonists. " 01/01/2002 - "The introduction of new, long-acting anticholinergics is a promising addition to the treatment of COPD and is expected to lead to improved treatment outcomes and improved patient compliance."
2.	Overactive Urinary Bladder (Overactive Bladder) 06/01/2011 - "Best treatment for overactive bladder if behavioral treatment and anticholinergics fail. " 06/01/2011 - "Best treatment for overactive bladder if behavioral treatment and anticholinergics fail. " 01/01/2012 - "During initial treatment of overactive bladder syndrome there was more symptomatic improvement when (a) anticholinergics were compared with bladder training alone, and (b) anticholinergics combined with bladder training were compared with bladder training alone. " 02/01/2006 - "Conservative therapy (especially oral anticholinergic agents) in children with overactive bladder is effective when applied appropriately (especially in patients with evident detrusor instability) with adequate follow up. " 09/01/2005 - "There is a lack of study on efficacy of apha-1 blocker administration combined with anticholinergics available in our hands for patients with BPH and overactive bladder. "
3.	Asthma (Bronchial Asthma) 01/01/2006 - "Therefore, an important consideration is how anticholinergic agents can be used to achieve clinically effective treatment of asthma. " 01/01/2003 - "This systematic review of randomized controlled trials suggests that the addition of inhaled anticholinergic agents to beta(2)-agonists is beneficial in children and adolescents, particularly those with severe exacerbations of asthma. " 01/01/2014 - "Inhaled anticholinergics given in addition to β2-agonists are effective in reducing hospital admissions in children presenting to the emergency department with a moderate to severe asthma exacerbation. " 09/16/2002 - "beta-Agonists are effective in acute asthma from the first year of life and anticholinergics have been shown to provide additional benefit from at least 18 months of age. " 09/01/2000 - "The efficacy of combination therapy adding multiple doses of anticholinergics to beta(2)-agonists to improve outcome has not been established in adults with acute severe asthma. "
4.	Tremor (Tremors) 08/01/2008 - "Classical rest tremors are improved by dopaminergic substances or anticholinergics. " 01/01/2014 - "Dystonic limb tremor may respond to anticholinergics. " 03/01/2005 - "Young Parkinson's patients with dominant, disabling tremor benefit from anticholinergics in addition to dopaminergic therapies. " 10/01/2003 - "Anticholinergics have been successfully used to treat tremor as well as sialorrhoea and urinary urgency. " 03/01/1999 - "We therefore conclude that dopaminergic substances are as effective as anticholinergics in patients with parkinsonian tremor and additionally improve other parkinsonian signs."
5.	Urinary Incontinence 12/01/2012 - "It is important to conduct urodynamic study before starting anticholinergic treatment of females with urinary incontinence to identify therapeutic data of poor prognosis, such as SUI and lower urinary tract obstruction, thus optimizing the therapeutic efficacy of anticholinergics." 10/01/2014 - "To evaluate the discontinuation rates of anticholinergics prescribed in patients with urinary incontinence (UI). " 07/01/2014 - "The treatment of urge-associated urinary incontinence is primarily with anticholinergic agents. " 06/01/2014 - "Intake of muscle relaxants and anticholinergics was associated with both urinary incontinence and severity of symptoms. " 01/01/2014 - "In the treatment of urgent forms of urinary incontinence, only 64.5% of urologists use M-anticholinergics. "

Related Drugs and Biologics

1.	Levodopa (L Dopa)
2.	Histamine Antagonists (Antihistamines)
3.	Botulinum Toxins (Botulinum Toxin)
4.	Adrenal Cortex Hormones (Corticosteroids)
5.	Benzodiazepines
6.	Atropine (Hyoscyamine)
7.	Dopamine Agonists (Dopamine Agonist)
8.	tiotropium (Spiriva)
9.	Bronchodilator Agents (Bronchodilators)
10.	oxybutynin (Tavor)

Related Therapies and Procedures

1.	Injections
2.	Drug Therapy (Chemotherapy)
3.	Catheters
4.	Anesthesia
5.	Pallidotomy