The use of multiple drugs administered to the same patient, most commonly seen in elderly patients. It includes also the administration of excessive medication. Since in the United States most drugs are dispensed as single-agent formulations, polypharmacy, though using many drugs administered to the same patient, must be differentiated from DRUG COMBINATIONS, single preparations containing two or more drugs as a fixed dose, and from DRUG THERAPY, COMBINATION, two or more drugs administered separately for a combined effect. (From Segen, Dictionary of Modern Medicine, 1992)
Networked: 1266 relevant articles (36 outcomes, 118 trials/studies)

Relationship Network

Therapy Context: Research Results


1. Uchida, Hiroyuki: 11 articles (07/2014 - 11/2003)
2. Correll, Christoph U: 10 articles (10/2015 - 01/2008)
3. Suzuki, Takefumi: 10 articles (01/2013 - 11/2003)
4. Watanabe, Koichiro: 9 articles (10/2013 - 11/2003)
5. Kashima, Haruo: 8 articles (01/2011 - 11/2003)
6. Evans, David C: 7 articles (11/2015 - 07/2011)
7. Yagi, Gohei: 7 articles (12/2009 - 11/2003)
8. Corsonello, Andrea: 6 articles (01/2015 - 03/2005)
9. Hanlon, Joseph T: 6 articles (10/2014 - 12/2003)
10. Marengoni, Alessandra: 5 articles (11/2015 - 05/2011)

Related Diseases

1. Heart Failure
2. Seizures (Seizure)
3. Schizophrenia (Dementia Praecox)
4. Drug Toxicity (Drug Safety)
09/01/1998 - "Geriatric patients exhibit a decline in the hepatic clearance of certain drugs and a marked increase in the frequency of adverse drug reactions, reflecting an increase in polypharmacy regimens and declines in liver volume and blood flow rather than reduced Phase I metabolism. "
07/31/2012 - "The combination of ART with polypharmacy significantly increases the chance of potentially serious drug-drug interactions (DDIs), which can lead to drug toxicity, poorer ART adherence, loss of efficacy of the coadministered medication, or virologic breakthrough. "
07/01/2004 - "While the intervention did not reduce hospitalisation episodes and only led to a modest improvement in quality of life, the development of a mutually acceptable form of face-to-face pharmacist/GP medication review, identification of potentially serious adverse drug reactions, identification of previously unreported complementary medicine use, and enhanced GP awareness of the risks of polypharmacy were positive outcomes of the study."
01/01/2015 - "The use of model organisms will remain central to the quest for drug discovery, but as we uncover molecular processes regulated by repurposed drugs and polypharmacy, studies of pharmacodynamics and pharmacokinetics, drug-drug interactions, drug toxicity, and therapeutic index will slowly become more prevalent in aging research. "
12/01/2014 - "Of the 50 studies identified, the majority that were rated good in terms of their adjustment for comorbidity demonstrated relationships between polypharmacy and a range of outcomes, including falls, fall outcomes, fall risk factors, adverse drug events, hospitalization, mortality, and measures of function and cognition. "
5. Epilepsy (Aura)

Related Drugs and Biologics

1. Clozapine (Clozaril)
2. Anticonvulsants (Antiepileptic Drugs)
3. carvedilol (Coreg)
4. Carbamazepine (Tegretol)
5. Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)
6. Cytochromes
7. Xylitol
8. Sotalol (Sotalol Hydrochloride)
9. Betaine (C.B.B.)
10. olive oil

Related Therapies and Procedures

1. Complementary Therapies (Alternative Medicine)
2. Therapeutics
3. Length of Stay
4. Drug Therapy (Chemotherapy)
5. Inappropriate Prescribing