Selenic Acid

A strong dibasic acid with the molecular formula H2SeO4. Included under this heading is the acid form, and inorganic salts of dihydrogen selenium tetraoxide.

Also Known As:

Ammonium Selenate; Calcium Selenate; Disodium Selenate; Magnesium Selenate; Monosodium Selenate; Potassium Selenate; Selenate; Selenic Acid, Ammonium Salt; Selenic Acid, Calcium Salt; Selenic Acid, Diammonium Salt; Selenic Acid, Disodium Salt, 75Se-Labeled; Selenic Acid, Disodium Salt, Decahydrate; Selenic Acid, Magnesium Salt; Selenic Acid, Monosodium Salt; Selenic Acid, Potassium Salt; Sodium Selenate; Acid, Selenic; Selenate, Ammonium; Selenate, Calcium; Selenate, Disodium; Selenate, Magnesium; Selenate, Monosodium; Selenate, Potassium; Selenate, Sodium

Networked: 125 relevant articles (13 outcomes, 26 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Inorganic Chemicals: 9
- Selenium Compounds: 199
  - Selenic Acid: 125
    - barium selenate: 7

Experts

1.	Hovens, Christopher M: 10 articles (01/2022 - 08/2010)
2.	O'Brien, Terence J: 10 articles (01/2022 - 03/2012)
3.	Velakoulis, Dennis: 7 articles (01/2022 - 03/2012)
4.	Malpas, Charles B: 6 articles (01/2022 - 01/2016)
5.	Vivash, Lucy: 6 articles (01/2022 - 01/2016)
6.	Corcoran, Niall M: 6 articles (01/2019 - 02/2004)
7.	Brodtmann, Amy: 5 articles (01/2022 - 01/2016)
8.	Liu, Qiong: 5 articles (12/2019 - 01/2014)
9.	Darby, David: 3 articles (01/2022 - 11/2020)
10.	Collins, Steven: 3 articles (01/2021 - 01/2016)

Related Diseases

1.	Insulin Resistance 12/01/2010 - "Significant improvement of insulin resistance of GK rats by treatment with sodium selenate." 12/01/2010 - "The present study suggested that sodium selenate treatment led to substantial improvement in peripheral insulin resistance." 04/01/2005 - "The present study was performed to examine the mechanism by which selenate ameliorates the insulin sensitivity in type II diabetic dbdb mice. " 12/01/2010 - "This amelioration of insulin resistance may be partly due to a direct effect of the sodium selenate on peripheral tissues. " 12/01/2010 - "We studied the effect of sodium selenate on insulin resistance of Goto-Kakizaki (GK) rats. "
2.	Seizures (Absence Seizure) 03/01/2012 - "The results demonstrated a dose-dependent protection of sodium selenate against 6-Hz stimulation induced seizures, and significant reduction in the total number of seizures following PTZ injection. " 01/01/2023 - "Casillas-Espinosa et al. found that sodium selenate not only reduced the number and severity of seizures in these model rats, but also improved their memory and learning ability. " 01/01/2023 - "Several rats stopped having seizures altogether even after the treatment had stopped, indicating that sodium selenate had a long-lasting protective effect. " 03/01/2012 - "Firstly the propensity of 6-Hz electrical corneal stimulation to induce seizures in adult mice was assessed following acute treatment with different doses of sodium selenate. " 03/01/2012 - "Here we investigated whether treatment with sodium selenate, a drug which reduces pathological hyperphosphorylated tau by enhancement of PP2A activity, would inhibit seizures in rodent models. "
3.	Memory Disorders (Memory Loss) 01/01/2023 - "Our results provide evidence that treatment with sodium selenate results in a sustained disease-modifying effect in chronically epileptic rats in the post-KA SE model of TLE, including improved comorbid learning and memory deficits. " 01/01/2017 - "Sodium selenate ameliorates some of the motor and memory deficits and the sensitivity observed with pentylenetetrazol (PTZ) treatments in Epm2b-/- mice. " 08/01/2010 - "Sodium selenate specifically activates PP2A phosphatase, dephosphorylates tau and reverses memory deficits in an Alzheimer's disease model."
4.	Neoplasms (Cancer) 10/05/2015 - "Selenate specifically sensitizes drug-resistant cancer cells by increasing apoptosis via G2 phase cell cycle arrest without P-GP inhibition." 09/01/2012 - "Nutritional and supranutritional levels of selenate differentially suppress prostate tumor growth in adult but not young nude mice." 06/08/2001 - "However, selenate showed no remarkable effect on all the steps of cancer cell invasion." 10/05/2015 - "Our findings may contribute to the development of selenate-based therapies for patients resistant to cancer drugs. " 09/01/2012 - "Taken together, dietary selenate at nutritional and supranutritional levels differentially inhibit tumor development in adult, but not young, nude mice engrafted with PC-3 prostate cancer cells."
5.	Tauopathies 01/01/2022 - "Sodium selenate as a therapeutic for tauopathies: A hypothesis paper." 01/01/2020 - "Here, we focused on the effects of chronic selenate application on synaptic transmission and synaptic plasticity in THY-Tau22 mice, a transgenic animal model of tauopathies. " 01/01/2020 - "Chronic Sodium Selenate Treatment Restores Deficits in Cognition and Synaptic Plasticity in a Murine Model of Tauopathy." 01/01/2020 - "Furthermore, selenate reduced the inactive demethylated catalytic subunit of protein phosphatase 2A (PP2A) in THY-Tau22 without affecting total PP2A.Our study provides evidence that chronic dietary selenate rescues functional synaptic deficits of tauopathy and identifies activation of PP2A as the putative mechanism."

Related Drugs and Biologics

1.	Selenium
2.	Selenious Acid (Selenite)
3.	Insulin (Novolin)
4.	Glucose (Dextrose)
5.	Selenomethionine (Sethotope)
6.	selenomethylselenocysteine (methylselenocysteine)
7.	Selenoproteins (Selenoprotein)
8.	DNA Adducts
9.	Hypoglycemic Agents (Hypoglycemics)
10.	Pentylenetetrazole (Metrazol)

Related Therapies and Procedures

1.	Chemoprevention
2.	Castration
3.	Therapeutics
4.	Intraocular Injections
5.	Withholding Treatment