Polycomb Repressive Complex 1

A multisubunit polycomb protein complex with affinity for CHROMATIN that contains methylated HISTONE H3. It contains an E3 ubiquitin ligase activity that is specific for HISTONE H2A and works in conjunction with POLYCOMB REPRESSIVE COMPLEX 2 to effect EPIGENETIC REPRESSION.

Networked: 70 relevant articles (0 outcomes, 4 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Cao, Qi: 2 articles (05/2019 - 01/2018)
2.	Liu, Qipeng: 2 articles (05/2019 - 01/2018)
3.	Zhu, Sen: 2 articles (05/2019 - 01/2018)
4.	Lowe, Scott W: 2 articles (12/2018 - 03/2007)
5.	Dimri, Goberdhan P: 2 articles (01/2018 - 07/2010)
6.	Walsh, Martin J: 2 articles (06/2016 - 06/2010)
7.	Zhou, Ming-Ming: 2 articles (06/2016 - 06/2010)
8.	Federico, Antonella: 2 articles (02/2015 - 01/2015)
9.	Forzati, Floriana: 2 articles (02/2015 - 01/2015)
10.	Fusco, Alfredo: 2 articles (02/2015 - 01/2015)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2021 - "Ring1b is a core subunit of polycomb repressive complex 1 (PRC1) and is essential in several high-risk cancers. " 01/01/2021 - "Chromobox 4 (CBX4) is a core component of polycomb-repressive complex 1 with important roles in cancer biology and tissue homeostasis. " 01/01/2019 - "Chromobox 6 (CBX6) is a subunit of Polycomb Repressive Complex 1 (PRC1) that mediates epigenetic gene repression and acts as an oncogene or tumor suppressor in a cancer type-dependent manner. " 01/01/2019 - "The Polycomb Repressive Complex 1 (PRC1) regulates epigenetic silencing and is manifestly linked to rare cancer types. " 01/01/2018 - "The oncogene BMI-1, a member of Polycomb Repressive Complex 1 (PRC1) plays essential roles in various human cancers and becomes an attractive therapeutic target. "
2.	Glioma (Gliomas) 04/01/2019 - "In the present study, we provided evidence that lncRNA candidates, selected by bioinformatic analysis and nervous system polycomb 1 (NSPc1), a key polycomb repressive complex 1 (PRC1) member, were highly expressed in glioma H4 cells in contrast to that noted in non‑cancerous cells. " 01/01/2013 - "Bmi1, a key component of the Polycomb Repressive Complex 1, is highly expressed in undifferentiated neural stem cells (NSC) as well as in several human cancers including high-grade gliomas--highly aggressive brain tumors. "
3.	Carcinoma (Carcinomatosis) 11/03/2022 - "Chromobox 8 (CBX8) is a core component of canonical polycomb repressive complex 1; however, its role in transcriptional regulation and in ovarian carcinoma progression has not been extensively investigated. " 02/20/2015 - "Several recent studies have reported the Polycomb Repressive Complex 1 member CBX7 as a tumor-suppressor gene whose expression progressively decreases in different human carcinomas in relation with tumor grade, malignant stage and poor prognosis. "
4.	Acute Promyelocytic Leukemia 12/09/2011 - "This study tested the hypothesis that Polycomb Repressive Complex 1 (PRC1) may play a negative role in the granulocytic differentiation of acute promyelocytic leukemia (APL) cells. "
5.	Polyploidy 01/01/2016 - "Through systematic expression studies, we detected that Cbx4/2, Rybp, and Ring1B [components of polycomb repressive complex 1 (PRC1)] are predominantly utilized in antimesometrial decidualization with polyploidy. "

Related Drugs and Biologics

1.	Long Noncoding RNA
2.	Proteins (Proteins, Gene)
3.	Histones (Histone)
4.	Chromatin
5.	Lysine (L-Lysine)
6.	Polycomb Repressive Complex 2
7.	Polycomb-Group Proteins
8.	Co-Repressor Proteins
9.	Histone Demethylases
10.	AMP-Activated Protein Kinases

Related Therapies and Procedures

1.	Therapeutics