Occludin

A MARVEL domain protein that binds to and regulates PROTEIN PHOSPHATASE 1. Occludin plays an important role in the formation and regulation of the TIGHT JUNCTION paracellular permeability barrier.

Also Known As:

Networked: 1483 relevant articles (89 outcomes, 130 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Sawada, Norimasa: 13 articles (08/2016 - 03/2002)
2.	Wang, Ping: 11 articles (01/2022 - 06/2011)
3.	Turner, Jerrold R: 11 articles (11/2019 - 10/2005)
4.	Kojima, Takashi: 10 articles (01/2020 - 12/2004)
5.	Xue, Yixue: 10 articles (01/2020 - 06/2011)
6.	Liu, Yang: 10 articles (12/2019 - 08/2015)
7.	Feng, Lin: 9 articles (03/2018 - 08/2015)
8.	Jiang, Jun: 9 articles (03/2018 - 08/2015)
9.	Jiang, Wei-Dan: 9 articles (03/2018 - 08/2015)
10.	Wu, Pei: 9 articles (03/2018 - 08/2015)

Related Diseases

1.	Inflammation (Inflammations) 01/01/2020 - "ACE significantly improved respiratory function by mitigating inflammation and oxidative stress and preserving AQP1 and Occludin expression in the lung in a rat model of LPS-induced ARDS." 04/26/2023 - "Immunohistochemical studies demonstrated that MNEC mice had significantly decreased occludin and ZO-1 expression compared to MTERM mice and increased ileal inflammation marked by the increased nuclear phospho-p65 of NFκB expression, revealing that microbial communities from patients who developed NEC had a negative effect on ileal barrier development and homeostasis. " 04/03/2023 - "Autophagy inhibited the constitutive degradation of occludin by preventing its caveolar endocytosis from the membrane and protected against inflammation-induced TJ barrier loss. " 12/01/2021 - "We assessed 39 inflammation-involved biomolecules (multiplex magnetic bead-based immunoassay), CEA and CA19-9 (ELISA assay) and the tissue expression levels of occludin and also pErk, STAT1 and STAT3 transcriptional factors (western blot). " 08/01/2021 - "The underlying mechanisms may involve in down-regulating the IKKß expression and elevating ZO-1 and occludin expression, thereby alleviating the inflammation of the esophagus and strengthening the barrier function of the esophageal epithelium."
2.	Colitis 11/01/2023 - "TNF-α and IFN-γ levels decreased and Occludin levels increased in colon tissue of Post-Vit D group compared to colitis group (p < 0.05). " 04/03/2023 - "Disruption of autophagy with acute Atg7 knockout in adult mice decreased intestinal occludin levels, increasing baseline colonic TJ permeability and exacerbating the effect of experimental colitis. " 05/31/2022 - "After colitis onset, treatment with MSPNPs was more effective than that with free MSPs in restoring the expressions of tight-junction-related genes (upregulation of occludin, ZO-1, JAM, MUC and FABP-2) and beneficial gut microbiota. " 01/01/2022 - "In mice with colitis, TEM revealed partial epithelial injury in the ileum, where the number of intercellular tight junctions and the expression levels of E‑cadherin, ZO‑1 and occludin were decreased, all of which were alleviated by anti‑TNF‑α and 5‑ASA treatment. " 10/01/2020 - "The antagomiR-200C prevents the decrease in occludin in enterocytes and intestine tissues of mice with colitis, maintaining the TJ barrier."
3.	Herpes Zoster 11/29/2022 - "Administration of XP + CS treatment in IBS-C rats significantly ameliorated the colonic histological parameters and exerted a positive effect on barrier integrity by restoring the expression of Occludin and zona occludens-1 (ZO-1). " 07/08/2022 - "licheniformis PF9 increased the expression levels of zona occludens 1 (ZO-1) and occludin (OCLN) in ETEC F4-infected IPEC-J2 cells. " 02/01/2022 - "In terms of functionality, all investigated TAs resulted in occludin redistribution and loss of zona occludens-1 and occludin co-localization. " 01/01/2022 - "MCPs enhanced levels of occludin (OCLN) and zona occludens protein-1 (ZO-1) in IBS-D mice to improve intestinal mucosal permeability. " 01/01/2022 - "The expression of epithelial phenotype markers E‑cadherin, occludin, zona occludens (ZO‑1), TGF‑β and Smad7 were measured. "
4.	Diarrhea 01/01/2021 - "Dietary YSE and orally CU increased the T-SOD, T-AOC, and CAT activity, villus height/crypt depth, jejunal occludin concentration; reduced the diarrhea rate of weaned piglets by 28%, gastric pH, ileal pH, cecal pH and urine pH, MDA, crypt depth; improved the diversity of cecal microflora. " 01/01/2021 - "Orally CU increased ADG, and ADFI, the T-SOD, T-AOC, and CAT activity, ileal villus height, villus height/crypt depth, jejunum occludin, and β-definsin-2 concentrations (P < 0.05); reduced the diarrhea rate and mortality, urine pH, the BUN and MDA concentrations, crypt depth (P < 0.05); improved the diversity of cecal microflora. " 01/01/2021 - "Dietary YSE increased ADG, the spleen and lymph node indexes, serum GLU, BUN, T-SOD, T-AOC, CAT concentrations, ileal villus height and villus height/crypt depth, jejunal occludin, and β-definsin-2 concentrations and ileal occludin concentration in weaned piglets (P < 0.05); decreased the diarrhea rate and mortality, rectal pH and urine pH, the BUN and MDA concentrations, crypt depth (P < 0.05); improved the diversity of cecal microflora. " 01/01/2022 - "Conclusion: EA treatment downregulates the submucosal EGC-derived GSNO expressions, repairs the intestinal barrier by upregulating the ZO-1 and occludin expression, and improves IBS-D symptoms, including visceral hypersensitivity, anxiety, and diarrhea, suggesting a potential role for EGC-derived GSNO in the regulation of intestinal homeostasis in IBS-D rats." 02/01/2018 - "However, the mice with stress-induced diarrhea exhibited decreased body weights, villus height to crypt depth ratios (V/C), and Occludin and Claudin1 expression. "
5.	Body Weight (Weight, Body) 05/16/2021 - "HFD mice exhibited duodenal mucosa damage with marked infiltration of immune cells and decreased expression of ZO-1 and occludin that coincided with increasing body weight. " 03/06/2019 - "A single dose of GT3 (200 mg/kg body weight (bwt)) administered 24 h before TBI suppressed cell death, prevented a decrease in villus height, increased crypt depth, attenuated intestinal permeability, and upregulated occludin level in the intestine compared to the vehicle treated group. " 01/01/2017 - "On Postnatal Day 7, the rats in the hyperoxic group exhibited significantly lower body weights, higher intestinal injury scores, lower numbers of goblet cells, higher I-FABP expression, lower occludin and ZO-1 expression, higher TLR4 and NF-κB expression, and higher intestinal permeability and bacterial translocation than did those in the room air group. " 07/14/2014 - "TRP supplementation led to an increase in occludin concentrations (P= 0·0009) and consecutively reduced liver weight:body weight ratio (P= 0·009) as well as overall hepatic fat accumulation in the N group (P= 0·05). " 08/30/2023 - "The effects of GQD on DSS-treated colitis were examined via daily body weight, DAI, colon length, HE staining, PAS staining, ZO-1 and Occludin immunohistochemical staining. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Tight Junction Proteins
3.	Claudin-1
4.	Cytokines
5.	Interleukin-6 (Interleukin 6)
6.	Messenger RNA (mRNA)
7.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
8.	Claudin-5
9.	Claudin-2
10.	Interleukins

Related Therapies and Procedures

1.	Intraperitoneal Injections
2.	Fecal Microbiota Transplantation
3.	Vagus Nerve Stimulation
4.	Vagotomy
5.	Transplantation