Thiazides

Heterocyclic compounds with SULFUR and NITROGEN in the ring. This term commonly refers to the BENZOTHIADIAZINES that inhibit SODIUM-POTASSIUM-CHLORIDE SYMPORTERS and are used as DIURETICS.

Networked: 443 relevant articles (32 outcomes, 34 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Fretheim, Atle: 9 articles (07/2007 - 09/2002)
2.	Campbell, Norman R C: 8 articles (05/2010 - 01/2004)
3.	Feldman, Ross D: 7 articles (05/2010 - 01/2004)
4.	Canadian Hypertension Education Program: 7 articles (05/2010 - 01/2004)
5.	Ogilvie, Richard I: 6 articles (05/2010 - 06/2005)
6.	Rabkin, Simon W: 6 articles (05/2010 - 06/2005)
7.	Larochelle, Pierre: 6 articles (05/2010 - 06/2005)
8.	Leiter, Lawrence A: 6 articles (05/2010 - 06/2005)
9.	Padwal, Raj: 6 articles (05/2010 - 06/2005)
10.	Khan, Nadia A: 6 articles (05/2010 - 01/2004)

Related Diseases

1.	Hypertension (High Blood Pressure) 02/01/2005 - "Though overall diuretic use seems to be increasing as compared with previous studies, there is room for improvement in the use of thiazides in multi-drug hypertension regimens." 09/01/1992 - "Thiazides remain, therefore, a safe and effective treatment for patients with hypertension." 10/01/2011 - "There are numerous reports of thiazide-induced hyponatraemia (TIH) and its incidence is growing as a result of increasing prescription after guidelines recommending thiazides as first-line treatment of essential hypertension have been introduced. " 07/01/2003 - "Thiazides first-line treatment for hypertension." 07/01/1999 - "Low-dose thiazides should be preferred for routine first-line treatment of hypertension unless they are contraindicated or there is a compelling indication for an alternative class of drug."
2.	Stroke (Strokes) 03/01/1993 - "On the basis of these trials, it is apparent that antihypertensive treatment with low-dose thiazides or beta-blockers, or the two in combination, can produce highly beneficial results in elderly patients, including a reduction in the incidence of stroke and other cardiovascular events as well as in total mortality. " 01/01/2001 - "Beta-blockers are less effective than thiazides as first line treatment and may only reduce stroke events. " 10/01/2014 - "No previous studies have assessed the influence of thiazides on functional prognosis after ischemic stroke. " 08/01/2004 - "Subsequent studies using thiazides at 'lower' doses showed prevention of both strokes and coronary events. " 01/01/2015 - "First-line thiazides caused less HF and stroke than first-line RAS inhibitors. "
3.	Renal Insufficiency (Renal Failure) 11/01/2012 - "Studies evaluating the efficacy of thiazides in renal insufficiency or dialysis were limited to those that included blood pressure measurements. " 02/01/2005 - "Thiazides are not believed to be efficient in advanced renal failure, but this is debated. " 01/01/2005 - "According to earlier findings this diuretic, in contrast to the thiazides, should not decrease the glomerular filtration rate (GFR) and be effective even in patients with advanced renal failure. " 04/02/2004 - "[Is it useful to treat a severe renal insufficiency with thiazides?]." 02/02/1980 - "Thiazides for hypertension with renal failure."
4.	Hypercalciuria 04/01/2015 - "We also demonstrate the efficacy of a treatment with thiazides in terms of hypercalciuria in the majority of patients." 11/01/1984 - "[Contribution of thiazides to the study of idiopathic hypercalciuria]." 04/01/2015 - "Treatment with thiazides effectively reduced hypercalciuria in most cases. " 03/01/2012 - "Re: effect of thiazides on bone mineral density in children with idiopathic hypercalciuria." 02/01/2012 - "Effect of thiazides on bone mineral density in children with idiopathic hypercalciuria."
5.	Nephrolithiasis 03/08/1986 - "Thiazides are considered to be effective in preventing recurrence of various types of nephrolithiasis, but the optimum dosage has not been established. " 07/01/1979 - "[Prevention of recurrent calcic nephrolithiasis with thiazides. " 04/01/2007 - "A review of the literature was performed for randomized, controlled trials with thiazides for calcium nephrolithiasis. " 09/01/2011 - "Thiazides diuretics in the treatment of nephrolithiasis: are we using them in an evidence-based fashion?" 04/01/2007 - "There is a lack of data on the metabolic effects of thiazides used to prevent recurrent calcium nephrolithiasis. "

Related Drugs and Biologics

1.	Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)
2.	Sodium Potassium Chloride Symporter Inhibitors (Loop Diuretics)
3.	Calcium
4.	Allopurinol (Remid)
5.	Peptidyl-Dipeptidase A (Angiotensin Converting Enzyme)
6.	Diuretics
7.	Potassium
8.	Angiotensin Receptor Antagonists
9.	Insulin (Novolin)
10.	Dihydropyridines

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Lithotripsy (Extracorporeal Shockwave Lithotripsy)
3.	Hormone Replacement Therapy (Therapy, Hormone Replacement)
4.	Transplants (Transplant)
5.	Polypharmacy