Benzothiadiazines

Heterocyclic compounds of a ring with SULFUR and two NITROGEN atoms fused to a BENZENE ring. Members inhibit SODIUM-POTASSIUM-CHLORIDE SYMPORTERS and are used as DIURETICS.

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Sulfur Compounds: 278
  - Thiazides: 1584
    - Benzothiadiazines: 3
  - Sulfones: 534
    - Sulfonamides: 2809
      - Benzothiadiazines: 3
        Diazoxide: 1200
        Chlorothiazide: 366
        Bendroflumethiazide: 203
        Polythiazide: 73
        Cyclopenthiazide: 46
        Methyclothiazide: 30
        Hydroflumethiazide: 22
        cyclothiazide: 20
        althiazide: 15
        dehydrosanol: 15
        bentazone: 14
        benzothiazide: 10
        flumethiazide: 10
        pipazethate: 6
        IDRA 21: 4
        S18986-1: 4
        penfluzide: 3
        triamterene drug combination bupranolol bemetizide: 3
        hypertane: 2
        setrobuvir: 2
        triamterene drug combination bemetizide: 2
        triamterene drug combination cyclothiazide: 2
        BPDZ 154: 1
        (2-(2,4,5-trifluorobenzyl)-7-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide-4-yl)acetic acid
        (2-(2,4,5-trifluorobenzyl)-7-fluoro-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide-4-yl)acetic acid
        (2-(4-bromo-2-fluorobenzyl)-7-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide-4-yl)acetic acid
        1,3,2,4-benzodithiadiazine
        1-((4-chlorophenyl)methyl)-3-benzyl-2,1,3-benzothiadiazin-4-one 2,2-dioxide
        1-benzyl-3-(benzyloxymethyl)-2,1,3-benzothiadiazin-4-one 2,2-dioxide
        2,3,3a,4-tetrahydro-1H-pyrrolo(2,1-c)(1,2,4) benzothiadiazine 5,5-dioxide
        2H-1,2,4-benzothiadiazine-1,1-dioxide
        2H-1,2,4-benzothiadiazine-1,1-dioxide-3-carboxylic acid
        3,4-dihydro-1,2,4-benzothiadiazine-1,1-dioxide
        3-amino-1,2,4-benzothiadi-azine 1,1-dioxide
        4-(4H-1,2,4-benzothiadiazine-3-yl)-2,6-bis(dimethylethyl)phenol-S,S-dioxide
        4-(6,7-dichloro-4H-1,2,4-benzothiadiazine-3-yl)-2,6-bis(1,1-dimethylethyl)phenol-S,S-dioxide
        4-cyclopropyl-7-fluoro-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide
        4-ethyl-7-fluoro-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide
        6-aminomethyl-3-methyl-4H-1,2,4-benzothiadiazine 1,1-dioxide
        6-chloro-3-cyclobutylamino-4H-1,2,4-benzothiadiazine 1,1-dioxide
        6-chloro-7-fluoro-3-isopropylamino-4H-1,2,4-benzothiadiazine 1,1-dioxide
        7-chloro-3-(1-hydroxy-2-propyl)amino-4H-1,2,4-benzothiadiazine 1,1-dioxide
        7-chloro-3-(3-pentylamino)-4H-1,2,4-benzothiadiazine 1,1-dioxide
        7-chloro-4-(2-fluoroethyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide
        7-chloro-4-cyclopropyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide
        7-chloro-9-(furan-3-yl)-2,3,3a,4-tetrahydro-1H-benzo(e)pyrrolo(2,1-c)(1,2,4)thiadiazine 5,5-dioxide
        8-chloro-3-isopropylamino-4H-1,2,4-benzothiadiazine 1,1-dioxide
        A 837093
        DU 717
        Goe 4962
        mebutizide
        N-(1-benzyl-3-(cyclopropylamino)-2-hydroxypropyl)-7-ethyl-1-methyl-3,4-dihydro-1H-(1,2,5)thiadiazepino(3,4,5-hi)indole-9-carboxamide 2,2-dioxide
        paraflutizide
        QM 7184
        RPR 104632
        tensigradyl
Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzothiadiazines: 3

Related Diseases

1.	Nephrolithiasis 02/08/1964 - "Consequently, the benzothiadiazines would not be expected to predispose to nephrolithiasis. "
2.	Diabetes Mellitus 11/01/1964 - "BENZOTHIADIAZINES AND DIABETES MELLITUS: A PRELIMINARY REPORT."
3.	Diabetes Insipidus 07/01/1963 - "Electrolyte conservation during the treatment of diabetes insipidus with benzothiadiazines."

Related Drugs and Biologics

1.	Electrolytes