Pinta

An infectious disease of the skin caused by Treponema carateum that occurs only in the western hemisphere. Age of onset is between 10 and 20 years of age. This condition is characterized by marked changes in the skin color and is believed to be transmitted by direct person-to-person contact.

Networked: 22 relevant articles (0 outcomes, 1 trials/studies)

Disease Context: Research Results

Related Diseases

1.	Yaws
2.	Treponemal Infections (Bejel)
3.	Syphilis
4.	Infection

Experts

1.	Stamm, Lola V: 1 article (11/2015)
2.	Briscoe, Adriana D: 1 article (07/2015)
3.	Smith, Gilbert: 1 article (07/2015)
4.	Laplana, César: 1 article (01/2015)
5.	Sevilla, Paloma: 1 article (01/2015)
6.	Pérez-González, Alfredo: 1 article (01/2015)
7.	Baquedano, Enrique: 1 article (01/2015)
8.	Arsuaga, Juan Luis: 1 article (01/2015)
9.	López-Martínez, Nieves: 1 article (01/2015)
10.	Arriaza, Mari Carmen: 1 article (01/2015)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Pinta:

1.	Penicillins (Penicillin)FDA Link 01/01/1987 - "A study was made of twenty-two biopsies of achromic lesions of Tikuna Indians, carriers of tertiary pinta, inhabitants of the Umariuassu island, on the Peruvian border, ten of the subjects had been treated two years previously with a single dose of penicillin. " 11/01/1953 - "[A clinical report of the use of penicillin in the treatment of 100 cases of pinta]." 08/01/1952 - "[Repository penicillin therapy of pinta in the Mexican peasant; clinical and serological survey]." 02/01/1952 - "Repository penicillin therapy of pinta in the Mexican peasant; a clinical and serologic survey." 12/10/1951 - "[Two years results after penicillin therapy of pinta]."
2.	Retinaldehyde (Retinal)IBA 05/25/2005 - "We demonstrate that PINTA functions subsequent to the production of vitamin A and is expressed and required in the retinal pigment cells. " 07/01/2015 - "CRAL_TRIO domain proteins are known to bind small lipophilic molecules such as retinal, inositol and Vitamin E and include such gene family members as PINTA, α-tocopherol transfer (ATT) proteins, retinoid binding proteins, and clavesins. "
3.	Carrier Proteins (Binding Protein)IBA 01/15/2010 - "After chromophore formation, the retinoid-binding protein Pinta acts downstream of NinaB and is required to supply photoreceptors with chromophore. " 05/25/2005 - "Rhodopsin formation in Drosophila is dependent on the PINTA retinoid-binding protein."
4.	AntigensIBA 01/01/1988 - "pallidum antigens, whereas adults with inactive pinta had less intense reactivity against fewer molecules. " 01/01/1988 - "Sera from all four patients with active pinta contained antibody to the 47-48 kilodalton major antigen; the intensity of reactivity and the number of antigens recognized increased with age and, presumably, duration of infection. " 06/01/1986 - "Most sera from patients with yaws or pinta were also reactive, a result indicating that a 4D antigen-like molecule also exists in the closely related pathogenic treponemes Treponema pertenue and Treponema carateum." 01/01/1988 - "Specificity of antibodies from patients with pinta for antigens of Treponema pallidum subspecies pallidum."
5.	AntibodiesIBA 07/25/1950 - "[Antibodies against Treponema carateum of pinta in the blood serum of pinta patients]." 01/01/1988 - "Specificity of antibodies from patients with pinta for antigens of Treponema pallidum subspecies pallidum."
6.	secondary SyphilisIBA 05/15/2005 - "The clinical appearance of pinta mimics secondary syphilis: another trap of treponematosis?" 06/01/1999 - "Positive serological findings for active syphilis and the detection of spirochetes in the trunk lesion indicated early secondary syphilis, but an extensive case history and the clinical appearance fulfilled all criteria for pinta. "
7.	CristobalIBA 10/27/2008 - "darwini were collected in the arid lowlands of 11 of the Galápagos Islands (Baltra, Española, Fernandina, Floreana, Isabela, Pinta, Pinzón, San Cristobal, Santa Cruz, Santiago and Seymour) and the humid highlands of a subset of 5 of them (Fernandina, Floreana, Isabela, Santa Cruz and Santiago). " 11/09/1999 - "Most unexpectedly, the lone survivor of the abingdoni subspecies from Pinta Island ("Lonesome George") is very closely related to tortoises from San Cristobal and Espanola, the islands farthest from the island of Pinta. "
8.	Vitamin EFDA LinkGeneric 07/01/2015 - "CRAL_TRIO domain proteins are known to bind small lipophilic molecules such as retinal, inositol and Vitamin E and include such gene family members as PINTA, α-tocopherol transfer (ATT) proteins, retinoid binding proteins, and clavesins. "
9.	Vitamin A (Retinol)FDA LinkGeneric 05/25/2005 - "We demonstrate that PINTA functions subsequent to the production of vitamin A and is expressed and required in the retinal pigment cells. " 05/25/2005 - "In a genetic screen for mutations that affect the biosynthesis of rhodopsin, we identified a novel CRAL-TRIO domain protein, prolonged depolarization afterpotential is not apparent (PINTA), which binds to all-trans-retinol. "
10.	Thiamine (Aneurin)FDA Link 12/01/1985 - "The results showed that a portion of "gallina pinta" contributed more than 25% of the daily recommended intake established by the National Institute of Nutrition "Salvador Zubirán" (INNSZ) for an adult man for energy, protein, iron, niacin and 24.3% thiamine and 21.0% calcium. "

Therapies and Procedures

1.	Transplants (Transplant) 11/09/1999 - "To rule out a possible recent transplant of Lonesome George, we sequenced DNA from three tortoises collected on Pinta in 1906. "
2.	Intramuscular Injections 11/04/2015 - "All stages of pinta are treatable with a single intramuscular injection of penicillin. "