Pinta

An infectious disease of the skin caused by Treponema carateum that occurs only in the western hemisphere. Age of onset is between 10 and 20 years of age. This condition is characterized by marked changes in the skin color and is believed to be transmitted by direct person-to-person contact.

Networked: 22 relevant articles (0 outcomes, 2 trials/studies)

Disease Context: Research Results

Related Diseases

1.	Yaws
2.	Syphilis
3.	Infections

Experts

1.	Cline, Gary W: 2 articles (11/2019 - 10/2017)
2.	Petersen, Kitt Falk: 2 articles (11/2019 - 10/2017)
3.	Shulman, Gerald I: 2 articles (11/2019 - 10/2017)
4.	Briscoe, Adriana D: 2 articles (12/2017 - 07/2015)
5.	Dufour, Sylvie: 1 article (11/2019)
6.	Macias-Muñoz, Aide: 1 article (12/2017)
7.	McCulloch, Kyle J: 1 article (12/2017)
8.	Butrico, Gina M: 1 article (10/2017)
9.	Peng, Liang: 1 article (10/2017)
10.	Perry, Rachel J: 1 article (10/2017)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Pinta:

1.	Penicillins (Penicillin)FDA Link 01/01/1987 - "A study was made of twenty-two biopsies of achromic lesions of Tikuna Indians, carriers of tertiary pinta, inhabitants of the Umariuassu island, on the Peruvian border, ten of the subjects had been treated two years previously with a single dose of penicillin. " 11/01/1953 - "[A clinical report of the use of penicillin in the treatment of 100 cases of pinta]." 11/01/2015 - "All stages of pinta are treatable with a single intramuscular injection of penicillin. " 08/01/1952 - "[Repository penicillin therapy of pinta in the Mexican peasant; clinical and serological survey]." 02/01/1952 - "Repository penicillin therapy of pinta in the Mexican peasant; a clinical and serologic survey."
2.	ReaginsIBA 04/01/1991 - "Three observations from our study support reactivity due to syphilis rather than yaws or pinta: (1) a similar percent of reactive rapid plasma reagin (RPR) card test results among MHA-TP reactors in the two age groups of women who were surveyed (42 vs. 49%) was observed; (2) women who were seroreactive in the MHA-TP had multiple risk factors for STD [low socioeconomic status (9.4%), urban residence (22.8%), first intercourse under 16 years of age (14.1%), and multiple sex partners (26.3%)], and (3) only sexually experienced women had reactive results in the MHA-TP test."
3.	Retinol-Binding Proteins (Retinoid Binding Proteins)IBA 01/15/2010 - "After chromophore formation, the retinoid-binding protein Pinta acts downstream of NinaB and is required to supply photoreceptors with chromophore. " 05/25/2005 - "Rhodopsin formation in Drosophila is dependent on the PINTA retinoid-binding protein." 07/01/2015 - "CRAL_TRIO domain proteins are known to bind small lipophilic molecules such as retinal, inositol and Vitamin E and include such gene family members as PINTA, α-tocopherol transfer (ATT) proteins, retinoid binding proteins, and clavesins. "
4.	Proteins (Proteins, Gene)FDA Link 12/01/2017 - "Vertebrate (cellular retinaldehyde-binding protein) and Drosophila (prolonged depolarization afterpotential is not apparent [PINTA]) proteins with a CRAL-TRIO domain transport retinal-based chromophores that bind to opsin proteins and are necessary for phototransduction. " 12/01/1985 - "The results showed that a portion of "gallina pinta" contributed more than 25% of the daily recommended intake established by the National Institute of Nutrition "Salvador Zubirán" (INNSZ) for an adult man for energy, protein, iron, niacin and 24.3% thiamine and 21.0% calcium. " 07/01/2015 - "CRAL_TRIO domain proteins are known to bind small lipophilic molecules such as retinal, inositol and Vitamin E and include such gene family members as PINTA, α-tocopherol transfer (ATT) proteins, retinoid binding proteins, and clavesins. "
5.	Retinaldehyde (Retinal)IBA 12/01/2017 - "Vertebrate (cellular retinaldehyde-binding protein) and Drosophila (prolonged depolarization afterpotential is not apparent [PINTA]) proteins with a CRAL-TRIO domain transport retinal-based chromophores that bind to opsin proteins and are necessary for phototransduction. " 07/01/2015 - "CRAL_TRIO domain proteins are known to bind small lipophilic molecules such as retinal, inositol and Vitamin E and include such gene family members as PINTA, α-tocopherol transfer (ATT) proteins, retinoid binding proteins, and clavesins. "
6.	Glucose (Dextrose)FDA LinkGeneric 10/06/2017 - "Here, we show that a positional isotopomer NMR tracer analysis (PINTA) method can be used to non-invasively assess rates of V CS and V PC fluxes using a combined NMR/gas chromatography-mass spectrometry analysis of plasma following infusion of [3-13C]lactate and glucose tracer. " 11/01/2019 - "In order to determine whether the glucose-alanine cycle regulates rates of hepatic mitochondrial oxidation in humans, we applied positional isotopomer NMR tracer analysis (PINTA) to assess rates of hepatic mitochondrial oxidation and pyruvate carboxylase flux in healthy volunteers following both an overnight (12 hours) and a 60-hour fast. "
7.	AntigensIBA 01/01/1988 - "pallidum antigens, whereas adults with inactive pinta had less intense reactivity against fewer molecules. " 01/01/1988 - "Sera from all four patients with active pinta contained antibody to the 47-48 kilodalton major antigen; the intensity of reactivity and the number of antigens recognized increased with age and, presumably, duration of infection. " 06/01/1986 - "Most sera from patients with yaws or pinta were also reactive, a result indicating that a 4D antigen-like molecule also exists in the closely related pathogenic treponemes Treponema pertenue and Treponema carateum." 01/01/1988 - "Specificity of antibodies from patients with pinta for antigens of Treponema pallidum subspecies pallidum."
8.	AntibodiesIBA 07/25/1950 - "[Antibodies against Treponema carateum of pinta in the blood serum of pinta patients]." 01/01/1988 - "Specificity of antibodies from patients with pinta for antigens of Treponema pallidum subspecies pallidum."
9.	OpsinsIBA 12/01/2017 - "Vertebrate (cellular retinaldehyde-binding protein) and Drosophila (prolonged depolarization afterpotential is not apparent [PINTA]) proteins with a CRAL-TRIO domain transport retinal-based chromophores that bind to opsin proteins and are necessary for phototransduction. "
10.	Tocopherols (Tocopherol)IBA 07/01/2015 - "CRAL_TRIO domain proteins are known to bind small lipophilic molecules such as retinal, inositol and Vitamin E and include such gene family members as PINTA, α-tocopherol transfer (ATT) proteins, retinoid binding proteins, and clavesins. "

Therapies and Procedures

1.	Therapeutics 08/01/1952 - "[Repository penicillin therapy of pinta in the Mexican peasant; clinical and serological survey]." 02/01/1952 - "Repository penicillin therapy of pinta in the Mexican peasant; a clinical and serologic survey." 12/10/1951 - "[Two years results after penicillin therapy of pinta]."
2.	Intramuscular Injections 11/01/2015 - "All stages of pinta are treatable with a single intramuscular injection of penicillin. "