Sodium-Activated Potassium Channels

Potassium channels whose activation is dependent on intracellular sodium concentrations.

Also Known As:

Potassium Channels, Sodium-Activated; K+ Channels, Sodium Activated; Potassium Channel, Sodium-Activated; Potassium Channels, Sodium Activated; Potassium Channels, Sodium Dependent; Sodium Activated Potassium Channel; Sodium Activated Potassium Channels; Sodium-Activated K+ Channels; Sodium-Dependent Potassium Channels; K+ Channels, Sodium-Activated; Potassium Channels, Sodium-Dependent; Sodium-Activated Potassium Channel

Networked: 10 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Bhattacharjee, Arin: 2 articles (10/2017 - 01/2017)
2.	Milligan, Carol J: 1 article (01/2021)
3.	Pachernegg, Svenja: 1 article (01/2021)
4.	Cole, Bethan A: 1 article (05/2020)
5.	Dejakaisaya, Hattapark: 1 article (05/2020)
6.	Fishwick, Colin W G: 1 article (05/2020)
7.	Johnson, Rachel M: 1 article (05/2020)
8.	Lippiat, Jonathan D: 1 article (05/2020)
9.	Muench, Stephen P: 1 article (05/2020)
10.	Pilati, Nadia: 1 article (05/2020)

Related Diseases

1.	Epilepsy (Aura) 01/01/2023 - "Gain of function variants in the sodium-activated potassium channel KCNT1 have been associated with pediatric epilepsy disorders. " 01/01/2019 - "Mutations in the sodium-activated potassium channel gene KCNT1 have been associated with nonlesional sleep-related hypermotor epilepsy (SHE). " 01/05/2016 - "Twelve sodium-activated potassium channel (KCNT1, Slack) genetic mutants have been identified from severe early-onset epilepsy patients. " 01/01/2021 - "The hKCNT1 gene encodes the weakly voltage-dependent sodium-activated potassium channel hKCNT1, and mutations in this gene cause a wide spectrum of seizure disorders, including severe autosomal dominant sleep-related hypermotor epilepsy (ADSHE) and epilepsy of infancy with migrating focal seizures (EIMFS), both conditions associated with drug-resistance. "
2.	Brain Diseases (Brain Disorder) 05/22/2020 - "Drug-resistant epileptic encephalopathies of infancy have been associated with KCNT1 gain-of-function mutations, which increase the activity of KNa1.1 sodium-activated potassium channels. " 11/01/2019 - "Mutations in the KCNT1 (Slack, KNa1.1) sodium-activated potassium channel produce severe epileptic encephalopathies. " 10/24/2017 - "A De Novo Mutation in the Sodium-Activated Potassium Channel KCNT2 Alters Ion Selectivity and Causes Epileptic Encephalopathy."
3.	Seizures (Absence Seizure) 01/01/2021 - "The hKCNT1 gene encodes the weakly voltage-dependent sodium-activated potassium channel hKCNT1, and mutations in this gene cause a wide spectrum of seizure disorders, including severe autosomal dominant sleep-related hypermotor epilepsy (ADSHE) and epilepsy of infancy with migrating focal seizures (EIMFS), both conditions associated with drug-resistance. "
4.	Hypercapnia 01/24/2008 - "The sodium-activated potassium channel Slack is modulated by hypercapnia and acidosis."
5.	Hyperalgesia 01/01/2017 - "Slick (Kcnt2) Sodium-Activated Potassium Channels Limit Peptidergic Nociceptor Excitability and Hyperalgesia."