RUNX1 Translocation Partner 1 Protein

A transcriptional co-repressor that contains a MYND-type zinc finger (MYND DOMAIN) at its C-terminal and functions as a homo-oligomer. It associates with DNA-binding transcription factors, other repressor proteins, and HISTONE ACETYLTRANSFERASES to repress expression of genes involved in cell growth and differentiation such as MATRIX METALLOPROTEINASE 7 and TCF12. A CHROMOSOMAL TRANSLOCATION involving the RUNX1T1 and CORE BINDING FACTOR ALPHA 2 SUBUNIT (RUNX1) genes frequently occurs in cells of leukemia patients; the resulting fusion protein (AML1-ETO or RUNX1-RUNX1T1) plays a critical role in leukemogenesis.

Also Known As:

Networked: 3 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Bui, Marilyn M: 1 article (05/2011)
2.	Chen, Dung-Tsa: 1 article (05/2011)
3.	Coppola, Domenico: 1 article (05/2011)
4.	Hafez, Naiel: 1 article (05/2011)
5.	Hakam, Ardeshir: 1 article (05/2011)
6.	Helm, James: 1 article (05/2011)
7.	Henderson-Jackson, Evita B: 1 article (05/2011)
8.	Hodul, Pamela: 1 article (05/2011)
9.	Kvols, Larry K: 1 article (05/2011)
10.	Malafa, Mokenge P: 1 article (05/2011)

Related Diseases

1.	Neoplasms (Cancer) 05/01/2011 - "This study was designed (1) to validate the differential expression of RUNX1T1 protein on independent test sets of metastatic and nonmetastatic PETs and (2) to determine if RUNX1T1 underexpression in primary tumors was predictive of liver metastases. "
2.	Neoplasm Metastasis (Metastasis) 05/01/2011 - "This study was designed (1) to validate the differential expression of RUNX1T1 protein on independent test sets of metastatic and nonmetastatic PETs and (2) to determine if RUNX1T1 underexpression in primary tumors was predictive of liver metastases. " 05/01/2011 - "RUNX1T1 protein is underexpressed in well-differentiated metastatic primary PETs relative to nonmetastatic primaries and emerges as a promising novel biomarker for prediction of liver metastases."
3.	Leukemia 07/01/2007 - "The eight twenty-one protein, ETO, is implicated in 12%-15% of acute human leukemias as part of a gene fusion with RUNX1 (also called AML1). " 01/31/2008 - "Leukemia-related abnormal Runx1 fusion protein AML1-ETO, which fuses the N-terminal 177 amino acid residues of the Runx1 protein in frame to ETO (eight-twenty-one) protein, also interacted with HIF-1alpha protein with greater ability than Runx1 itself. "

Related Drugs and Biologics

1.	Core Binding Factor Alpha 2 Subunit
2.	Biomarkers (Surrogate Marker)
3.	Proteins (Proteins, Gene)
4.	Amino Acids