Transforming Protein 3 Src Homology 2 Domain-Containing

An SHC-signaling adaptor protein that links GROWTH FACTOR RECEPTORS to SIGNAL TRANSDUCTION PATHWAYS in neurons, including NEUROTROPHINS signaling in the CENTRAL NERVOUS SYSTEM.

Also Known As:

Src Homology 2 Domain-Containing, Transforming Protein 3; SHC3 (Src Homology 2 Domain-Containing) Protein; SHC3 Protein; SHCC Protein; Src Homology 2 Domain-Containing-Transforming Protein C3; Src Homology 2 Domain Containing Transforming Protein C3; Src Homology 2 Domain Containing, Transforming Protein 3

Networked: 6 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Arbustini, Eloisa: 3 articles (01/2020 - 04/2010)
2.	Magrassi, Lorenzo: 3 articles (01/2020 - 04/2010)
3.	Azzalin, Alberto: 2 articles (01/2020 - 11/2014)
4.	Chen, Wei: 1 article (07/2021)
5.	Ma, Jing: 1 article (07/2021)
6.	Zhang, Jian: 1 article (07/2021)
7.	Zhang, Ning: 1 article (07/2021)
8.	Zhao, Chedong: 1 article (07/2021)
9.	Basello, Katia: 1 article (01/2020)
10.	Bezzi, Paola: 1 article (01/2020)

Related Diseases

1.	Neuroblastoma 02/05/2009 - "In this study, we analysed the expression levels of ShcA and ShcC proteins in 46 neuroblastoma samples and showed that a significantly higher level of ShcC protein is observed in neuroblastomas with poor prognostic factors such as advanced stage and MYCN amplification (P<0.005), whereas the expression level of ShcA showed no significant association with these factors. "
2.	Glioblastoma (Glioblastoma Multiforme) 11/01/2014 - "Shc3 protein levels are high in human glioblastoma but they decrease in vitro. " 01/01/2020 - "Here we show that in human glioblastoma cells maintained in exhausted medium, SHC adaptor protein 3 (SHC3) increases due to down-regulation of SHC3 protein degradation. "
3.	Colorectal Neoplasms (Colorectal Cancer) 07/01/2021 - "To determine the prognostic value of Src homology 2 domain-containing transforming protein C3 (SHC3) in colorectal cancer (CRC). " 07/01/2021 - "The expression and prognostic value of Src homology 2 domain-containing transforming protein C3 (SHC3) and its potential role in colorectal cancer."
4.	Glioma (Gliomas) 11/01/2014 - "Our results suggest that in gliomas cell density modulates Shc3 protein levels and its activity, at least in part, through Fak activation. "
5.	Ependymoma 04/01/2010 - "In ependymomas EDG3 and SHC3 amplification increased Shc3 protein levels while EDG3 was less affected. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)