Type VII Secretion Systems

Bacterial secretion systems found in bacteria that have a MYCOLIC ACID-containing outer membrane such as MYCOBACTERIACEAE; Corynebacteriaceae; and NOCARDIACEAE. These are also known as ESX secretion systems because the first to be discovered is involved in secreting major virulence factors EsxA and EsxB. There are several subtypes of T7SSs including ESX-1, ESX-2, ESX-3, ESX-4, and ESX-5 secretion systems. The subtypes share some core components including an inner membrane channel-forming ATPase complex, a membrane-anchored mycosin, and a second channel that spans the outer mycolic acid-containing membrane.

Also Known As:

Networked: 33 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Bitter, Wilbert: 5 articles (01/2019 - 11/2011)
2.	Brosch, Roland: 5 articles (01/2019 - 03/2015)
3.	Majlessi, Laleh: 3 articles (01/2017 - 03/2015)
4.	Simeone, Roxane: 3 articles (01/2017 - 06/2015)
5.	Abdallah, Abdallah M: 2 articles (01/2019 - 11/2011)
6.	Ummels, Roy: 2 articles (01/2019 - 10/2016)
7.	Frigui, Wafa: 2 articles (01/2017 - 06/2015)
8.	Sayes, Fadel: 2 articles (01/2017 - 01/2017)
9.	Korotkov, Konstantin V: 2 articles (10/2016 - 08/2015)
10.	Bitter, W: 1 article (01/2021)

Related Diseases

1.	Infections 11/25/2020 - "Here, we use human induced pluripotent stem cell-derived macrophages (iPSDMs) to study the human macrophage response to Mtb infection and the role of the ESX-1 type VII secretion system. " 11/01/2011 - "In this study, we address the contribution of ESX-1 and ESX-5--two homologous type VII secretion systems of mycobacteria that secrete distinct sets of immune modulators--during the macrophage infection cycle. " 01/01/2021 - "Pathogenic mycobacteria have up to five different type VII secretion systems, called ESX-1 to ESX-5, which play distinct roles for the pathogen during growth or infection. " 01/01/2021 - "We have discovered that lytic phage infection induces transcription of type VIIb secretion system (T7SS) genes in the pathobiont Enterococcus faecalis. " 11/01/2011 - "These results reveal distinct roles for two different type VII secretion systems during infection and shed light on how virulent mycobacteria manipulate the host cell in various ways to replicate and spread."
2.	Tuberculosis (Tuberculoses) 01/01/2023 - "tuberculosis to have a functional ESX-1 type VII secretion system. " 01/01/2020 - "tuberculosis Type VII secretion system ESX-1 to permeabilize the phagosomal membranes of infected macrophages. " 01/01/2020 - "Following mycobacterial entry into macrophages the ESX-1 type VII secretion system promotes phagosomal permeabilization and type I IFN production, key features of tuberculosis pathogenesis. " 10/18/2016 - "Understanding the essential role of mycosins in type VII secretion systems, which play central roles in the virulence and viability of pathogenic mycobacteria, may provide new intervention strategies to treat tuberculosis." 06/01/2015 - "tuberculosis genome harbours a total of five gene clusters potentially coding for type VII secretion systems, designated ESX-1 - ESX-5, with ESX-4 being the most ancient system from which other ESX systems seem to have evolved by gene duplication and gene insertion events. "
3.	Rupture 12/20/2022 - "IMPORTANCE Pathogenic mycobacteria, such Mycobacterium tuberculosis and Mycobacterium marinum, use a type VII secretion system (T7SS) subtype, called ESX-1, to mediate intracellular survival via phagosomal rupture and subsequent translocation of the mycobacterium to the host cytosol. " 01/01/2017 - "A feature of BCG is the partial deletion of the ESX-1 type VII secretion system, which governs phagosomal rupture and cytosolic pattern recognition, key intracellular phenotypes linked to increased immune signaling. " 01/01/2017 - "This small protein, which is secreted by the type VII secretion system ESX-1 (T7SS/ESX-1), is involved in phagosomal rupture and cell death induced by virulent mycobacteria inside host phagocytes. "
4.	Disease Progression 06/14/2013 - "Mycobacterium tuberculosis encodes five nonredundant ESX secretion systems, with ESX-1 being particularly important to disease progression. " 01/01/2019 - "tuberculosis has five of them: ESAT-6 secretion systems (ESX) 1 to 5. ESX-1 has long been recognized as a major cause of attenuation of the FDA-licensed vaccine Mycobacterium bovis BCG, but its importance in disease progression and transmission has recently been elucidated in more detail. "
5.	Coinfection 02/26/2016 - "We observed down-regulation of toxin-antitoxin (TA) modules, up-regulation of cation transporters, Type VII (Esx) secretion systems, proteins involved in cell wall lipid or protein metabolism, glyoxalate pathway and branched chain amino-acid synthesis during co-infection. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Type VII Secretion Systems
3.	Vaccines
4.	Virulence Factors (Pathogenicity Factors)
5.	Phosphates (Orthophosphate)
6.	Phosphate-Binding Proteins
7.	ATP-Binding Cassette Transporters (ABC Transporters)
8.	Trehalose
9.	N-Acetylmuramoyl-L-alanine Amidase (Autolysin)
10.	Lipids