Virulence Factors (Pathogenicity Factors)

Those components of an organism that determine its capacity to cause disease but are not required for its viability per se. Two classes have been characterized: TOXINS, BIOLOGICAL and surface adhesion molecules that effect the ability of the microorganism to invade and colonize a host. (From Davis et al., Microbiology, 4th ed. p486)

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Networked: 2755 relevant articles (31 outcomes, 199 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Yamaoka, Yoshio: 13 articles (01/2015 - 06/2002)
2.	Potempa, Jan: 11 articles (01/2015 - 10/2003)
3.	Schlievert, Patrick M: 10 articles (01/2015 - 02/2002)
4.	Ladant, Daniel: 7 articles (10/2014 - 10/2003)
5.	Hultgren, Scott J: 7 articles (03/2014 - 01/2005)
6.	Finlay, B Brett: 7 articles (01/2012 - 05/2005)
7.	Bonacorsi, S: 6 articles (11/2015 - 07/2007)
8.	Leppla, Stephen H: 6 articles (10/2015 - 12/2009)
9.	Casadevall, Arturo: 6 articles (08/2015 - 01/2008)
10.	Bagheri, Nader: 6 articles (08/2015 - 01/2013)

Related Diseases

1.	Infection 01/01/2014 - "While human or animal models are often considered the gold standard experimental system for defining virulence factors, cell culture-based infection models have proven useful for identifying important virulence factors and for examining the interactions between pathogens and the epithelial barrier. " 10/01/2007 - "aeruginosa lung infection that AZM treatment results in the suppression of QS-regulated virulence factors, significantly improves the clearance of P. " 10/01/2009 - "Analysis of stx subtypes and detection of additional virulence factors in eae-negative strains may help to better assess the risk of such strains for causing human infection." 07/01/2015 - "Complex model systems such as the bovine model have helped in understanding key virulence factors needed for infection. " 09/26/2014 - "The bacterial envelope possesses diverse functions, including protection against environmental stress and virulence factors for host infection. "
2.	Urinary Tract Infections (Urinary Tract Infection) 10/01/2005 - "Determination of bacterial virulence factors causing urinary tract infections in children may be helpful in the prognosis of the course of the disease." 04/01/2002 - "Aims of this study are to identify host and Escherichia coli virulence factors associated with upper urinary tract infection (UTI) by comparing them with those for lower UTI and determining the association between major predisposing host factors for upper UTI and urovirulence genes for E coli. " 04/01/1996 - "The relationship between the presence of bacterial virulence factors and the severity of urinary tract infection (UTI) was analized in this study. " 03/01/1991 - "Earlier studies revealed several phenotypic Escherichia coli virulence factors that influenced both the anatomic level and severity of urinary tract infection. " 03/01/1991 - "Most of the information available concerning virulence factors of uropathogens is based on studies of Escherichia coli, the commonest cause of urinary tract infections. "
3.	Periodontal Diseases (Periodontal Disease) 01/01/1991 - "However, concrete evidence is not yet available that indicates that complement activation occurs in human periodontal disease and is important in either its pathogenesis or in protection against bacterial virulence factors." 01/01/2013 - "This data indicates that Aa LtxA exerts a greater effect on bone loss than Cdt in this rat model of periodontal disease and supports the utility of this model to dissect specific virulence factors as they relate to immunopathology in studies of Aa-induced disease. " 06/01/2010 - "The virulence factors of Candida spp. increase host susceptibility to proliferation of these microorganisms and are likely to be important in the study of periodontal disease. " 09/01/2015 - "Knowledge about the pathogenic process in the progression of periodontal disease indicates that the central cause of periodontal disease is the loss of a healthy balance between microbial virulence factors and the host's inflammatory response. " 01/01/2014 - "Porphyromonas gingivalis is a major etiological agent of periodontal diseases and the outer membrane vesicles (OMVs) contain virulence factors such as LPS and gingipains. "
4.	Whooping Cough (Pertussis) 01/01/2013 - "Despite considerable success in study of Bordetella pertussis virulence factors, pathogenesis of whooping cough, duration of B. " 12/01/2015 - "pertussis virulence factors. " 01/01/2015 - "Since many virulence factors are involved in the pathogenesis of pertussis, beside the toxin-neutralizing activity, the direct bactericidal activity is essential in anti-pertussis immunity. " 10/21/2014 - "pertussis strain which does not express any of the virulence factors but expresses the avirulent phenotype; we observed that the protective ability of such OMVs was lower than that of OMVs obtained from virulent B. " 12/01/2013 - "pertussis virulence factors to modulate host immune responses and the mechanisms employed, which have been the subject of extensive research in the recent years, both in murine and human experimental systems. "
5.	Bacterial Infections (Bacterial Infection) 01/01/2004 - "The acquisition of knowledge about PAI, their structure, their mobility, and the pathogenicity factors they encode not only is helpful in gaining a better understanding of bacterial evolution and interactions of pathogens with eukaryotic host cells but also may have important practical implications such as providing delivery systems for vaccination, tools for cell biology, and tools for the development of new strategies for therapy of bacterial infections." 07/15/2003 - "In the present study, we detected the presence of several genes encoding for putative virulence factors and phenotypic activities that may play an important role in bacterial infection. " 02/01/1994 - "As in vitro studies have shown, gastroenteritic salmonellae seem to possess a number of so-called virulence factors that help them to evade the host's defenses against bacterial infection. " 01/01/1991 - "Studies on the molecular structure and immunological properties of pneumococcal virulence factors have provided general knowledge for the chemical basis of immunogenicity and prevention of bacterial infection. " 05/01/2015 - "Virulence factors, and more particularly pore-forming toxins, play a key role in increasing morbidity and mortality caused by drug-resistant bacterial infections. "

Related Drugs and Biologics

1.	Vaccines
2.	Antigens
3.	Proteins (Proteins, Gene)
4.	Anti-Bacterial Agents (Antibiotics)
5.	DNA (Deoxyribonucleic Acid)
6.	Antibodies
7.	Bacterial Capsules
8.	Penicillins (Penicillin)
9.	Gram's stain
10.	Immunoglobulin A (IgA)

Related Therapies and Procedures

1.	Catheters
2.	Blood Transfusion (Blood Transfusions)
3.	Therapeutics
4.	Immunotherapy
5.	Drug Therapy (Chemotherapy)