carbamic acid N- methyl- N- ((3- (4- pyridinyl)phenyl)methyl)- 4'- (aminocarbonyl)(1,1'- biphenyl)- 4- yl ester

an ABHD6 inhibitor; structure in first source

Also Known As:

N-methyl-N-((3-(4-pyridinyl)phenyl)methyl)-4'-(aminocarbonyl)(1,1'-biphenyl)-4-yl ester, carbamic acid; WWL70

Networked: 7 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Biphenyl Compounds: 7
        carbamic acid N-methyl-N-((3-(4-pyridinyl)phenyl)methyl)-4'-(aminocarbonyl)(1,1'-biphenyl)-4-yl ester: 7
- Carboxylic Acids: 973
  - Acyclic Acids
    - Carbamates: 945
      - carbamic acid N-methyl-N-((3-(4-pyridinyl)phenyl)methyl)-4'-(aminocarbonyl)(1,1'-biphenyl)-4-yl ester: 7

Experts

1.	Zhang, Yumin: 4 articles (01/2018 - 04/2013)
2.	Tanaka, Mikiei: 3 articles (01/2018 - 12/2015)
3.	Wen, Jie: 3 articles (01/2018 - 12/2015)
4.	Symes, Aviva J: 2 articles (01/2018 - 10/2017)
5.	Alhouayek, Mireille: 1 article (01/2019)
6.	Ameraoui, Hafsa: 1 article (01/2019)
7.	Bottemanne, Pauline: 1 article (01/2019)
8.	Muccioli, Giulio G: 1 article (01/2019)
9.	Paquot, Adrien: 1 article (01/2019)
10.	Bernal-Chico, Ana: 1 article (10/2018)

Related Diseases

1.	Traumatic Brain Injuries (Traumatic Brain Injury) 04/01/2013 - "Using a mouse model of traumatic brain injury (TBI), we found that post-insult chronic treatment with a selective ABHD6 inhibitor WWL70 improved motor coordination and working memory performance. " 10/01/2017 - "Our recent studies have shown that a selective ABHD6 inhibitor WWL70 has anti-inflammatory and neuroprotective effects in animal models of traumatic brain injury and multiple sclerosis. "
2.	Multiple Sclerosis 10/01/2018 - "ABHD6 blockade has been proposed as novel strategy to treat multiple sclerosis (MS), based on the observation that the inhibitor WWL70 exerts protective anti-inflammatory effects in experimental autoimmune encephalomyelitis (EAE). " 10/01/2017 - "Our recent studies have shown that a selective ABHD6 inhibitor WWL70 has anti-inflammatory and neuroprotective effects in animal models of traumatic brain injury and multiple sclerosis. "
3.	Pneumonia (Pneumonitis) 01/01/2019 - "The α/β-hydrolase domain 6 inhibitor WWL70 decreases endotoxin-induced lung inflammation in mice, potential contribution of 2-arachidonoylglycerol, and lysoglycerophospholipids." 01/01/2019 - "The α/β-hydrolase domain 6 inhibitor WWL70 decreases endotoxin-induced lung inflammation in mice, potential contribution of 2-arachidonoylglycerol, and lysoglycerophospholipids."
4.	Neuralgia (Stump Neuralgia) 01/08/2018 - "WWL70 protects against chronic constriction injury-induced neuropathic pain in mice by cannabinoid receptor-independent mechanisms."
5.	Inflammation (Inflammations) 10/01/2017 - "However, the role of ABHD6 in the neuroinflammatory response and the mechanisms by which WWL70 suppresses inflammation has not yet been elucidated in reactive microglia. "

Related Drugs and Biologics

1.	Neuroprotective Agents
2.	Cannabinoid Receptors (Cannabinoid Receptor)
3.	Dinoprostone (PGE2)
4.	Hydrolases
5.	Endotoxins
6.	glyceryl 2-arachidonate (2-arachidonoylglycerol)