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SGI-1027

inhibits DNA methyltransferase 1; structure in first source

Also Known As:

N-(4-(2-amino-6-methylpyrimidin-4-ylamino)phenyl)-4-(quinolin-4-ylamino)benzamide

Networked: 9 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrimidines: 510
    - SGI-1027: 9
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Quinolines: 146
      - Aminoquinolines: 29
        SGI-1027: 9

Experts

1.	Ahn, Hyunjun Max: 1 article (01/2021)
2.	Du, Yuhong: 1 article (01/2021)
3.	Fan, Dacheng: 1 article (01/2021)
4.	Fu, Haian: 1 article (01/2021)
5.	Ivanov, Andrey A: 1 article (01/2021)
6.	Liang, Bo: 1 article (01/2021)
7.	Qian, Kun: 1 article (01/2021)
8.	Troha, Aidan Henry: 1 article (01/2021)
9.	Yang, Xuan: 1 article (01/2021)
10.	Kim, D-H: 1 article (05/2020)

Related Diseases

1.	Neoplasms (Cancer) 05/15/2009 - "Treatment of different cancer cell lines with SGI-1027 resulted in selective degradation of DNMT1 with minimal or no effects on DNMT3A and DNMT3B. " 07/01/2011 - "In particular, cancer cells harboring DNMT3B gene amplification are less sensitive to the decrease in cell viability caused by 5-azacytidine (Vidaza), 5-aza-2-deoxycytidine (Decitabine), and SGI-1027. " 12/01/2015 - "By utilizing this system, we assessed RG108, SGI-1027 and nanaomycin A, three novel DNA methyltransferase inhibitors that have not been tested in neuroblastoma cell lines so far, for their potential of synergistic anti-tumor activity in combination with doxorubicin. "
2.	Leukemia 03/01/2014 - "These compounds possessed cytotoxicity against leukemia KG-1 cells in the micromolar range, comparable with the cytotoxicity of the reference compound, SGI-1027. " 03/15/2013 - "Synthetic approaches to DNMT inhibitor SGI-1027 and effects on the U937 leukemia cell line."
3.	Chronic Wasting Disease 05/01/2020 - "Herein, we confirm the elimination of PrP^(Sc) in chronic wasting disease (CWD) prion-infected neurons by SGI-1027, and pinpoint the binding region of human prion protein to SGI-1027. "
4.	Prion Diseases (Transmissible Spongiform Encephalopathies) 05/01/2020 - "SGI-1027 is broadly functional against various prion disease types, including human prions. "
5.	Neuroblastoma 12/01/2015 - "By utilizing this system, we assessed RG108, SGI-1027 and nanaomycin A, three novel DNA methyltransferase inhibitors that have not been tested in neuroblastoma cell lines so far, for their potential of synergistic anti-tumor activity in combination with doxorubicin. "

Related Drugs and Biologics

1.	Prions
2.	Methyltransferases
3.	Doxorubicin (Adriamycin)
4.	DNA (Deoxyribonucleic Acid)
5.	Azacitidine (5 Azacytidine)
6.	Decitabine
7.	Prion Proteins
8.	RG108
9.	nanaomycin A